(3Z)-3-hydroxyimino-1-methyl-6-phenylazepin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: (3Z)-3-hydroxyimino-1-methyl-6-phenylazepin-2-one
• 化学式: C₁₃H₁₂N₂O₂
• 分子量: 228.25
• InChiKey: PXSHXDDBOUXGSV-OWBHPGMISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Human airway stem cells in lung epithelial engineering
  申请人：The General Hospital Corporation

  公开号：US10624992B2

  公开（公告）日：2020-04-21

  Methods of using human airway stem cells in lung epithelial engineering, optionally wherein the cells are contacted with a gamma secretase inhibitor, bioartificial airway organs produced thereby, and the use thereof, e.g., for transplantation. Also methods of treating a bio-artificial matrix with Tenascin-C and/or fibrillin 2.

  在肺上皮工程中使用人气道干细胞的方法，其中细胞可选择与γ分泌酶抑制剂接触，由此产生的生物人工气道器官及其用途，例如用于移植。还包括用Tenascin-C和/或纤维蛋白2处理生物人工基质的方法。
• Treating hearing loss
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US10898492B2

  公开（公告）日：2021-01-26

  This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, e.g., adolescents and adults.

  本发明涉及使用某些γ分泌酶抑制剂治疗与耳蜗毛细胞缺失有关的听力损失的方法，例如，在新生后动物（如青少年和成年人）中使用这些抑制剂治疗由噪声暴露引起的耳蜗毛细胞缺失。
• Treatment of hearing loss by inhibition of casein kinase 1
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：US11185536B2

  公开（公告）日：2021-11-30

  Methods for treating hearing loss that include administering an inhibitor, e.g., a small molecule inhibitor, of casein kinase 1, preferably in combination with a treatment that stimulates Atoh1 gene expression, e.g., a gamma-secretase inhibitor, an Atoh1 stimulatory compound, or a GSK-3-beta inhibitor.

  治疗听力损失的方法，包括施用酪蛋白激酶1的抑制剂，如小分子抑制剂，最好与刺激Atoh1基因表达的治疗剂，如γ-分泌酶抑制剂、Atoh1刺激化合物或GSK-3-beta抑制剂联合使用。
• Efficient delivery of therapeutic molecules to cells of the inner ear
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US11370823B2

  公开（公告）日：2022-06-28

  Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

  提供了诱导内耳细胞进入细胞周期和增殖的组合物。特别是，通过服用能激活 Myc 和 Notch 的组合物来诱导毛细胞增殖。通过抑制 Myc 和 Notch 的活性或激活 Atoh1，诱导支持细胞向毛细胞转分化。治疗方法包括在细胞内将这些分子输送到特定的治疗靶点。
• METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP2892523A1

  公开（公告）日：2015-07-15