5,6,7-Trihydroxy-1,1,1-triphenylheptan-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5,6,7-Trihydroxy-1,1,1-triphenylheptan-4-one
• 英文别名: 5,6,7-trihydroxy-1,1,1-triphenylheptan-4-one
• 化学式: C₂₅H₂₆O₄
• 分子量: 390.5
• InChiKey: VPKXLFYPBGMFSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TREATMENT OF MEDIUM-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：EP2838522A1

  公开（公告）日：2015-02-25
• Treatment of Medium-Chain Acyl-CoA Dehydrogenase Deficiency
  申请人：University of Pittsburgh - of the Commonwealth System of Higher Education

  公开号：US20150216824A1

  公开（公告）日：2015-08-06

  The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can serve as a substrate for medium chain acyl-CoA dehydrogenase. In non-limiting embodiments, phenylbutyrate and/or another source of phenylacetate is administered as a chaperone treatment to patients suffering from medium chain acyl-CoA dehydrogenase deficiency.
• TREATMENT OF MEDIUM-CHAIN ACYL-CoA DEHYDROGENASE DEFICIENCY
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20160166522A1

  公开（公告）日：2016-06-16

  The present invention provides for methods and compositions for treating medium chain acyl-CoA dehydrogenase deficiency. It is based, at least in part, on the discovery that phenylbutyrate can serve as a substrate for medium chain acyl-CoA dehydrogenase. In non-limiting embodiments, phenylbutyrate and/or another source of phenylacetate is administered as a chaperone treatment to patients suffering from medium chain acyl-CoA dehydrogenase deficiency.
• US9283200B2
  申请人：——

  公开号：US9283200B2

  公开（公告）日：2016-03-15
• US9649285B2
  申请人：——

  公开号：US9649285B2

  公开（公告）日：2017-05-16