(2R)-3-[2-[3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(trityloxymethyl)phenoxy]-2-methylpropanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (2R)-3-[2-[3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(trityloxymethyl)phenoxy]-2-methylpropanoic acid
• 化学式: C₄₅H₅₁NO₄
• 分子量: 669.9
• InChiKey: WEOGDJOXJAHHAS-JENSWOFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  50
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PROCESS FOR THE PREPARATION OF 2-(3-N,N-DIISOPROPYLAMINO-1-PHENYLPROPYL)-4-HYDROXYMETHYL-PHENOL AND ITS DERIVATIVES<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE 2-(3-N,N-DIISOPROPYLAMINO-1-PHÉNYLPROPYL)-4-HYDROXYMÉTHYLPHÉNOL ET DE SES DÉRIVÉS
  申请人：CAMBREX PROFARMACO MILANO S R L

  公开号：WO2014012832A1

  公开（公告）日：2014-01-23

  The invention concerns a process for the preparation of 2-(3-N,N- diisopropylamino-l-phenylpropyl)-4-hydroxymethyl-phenol and its derivatives, particularly the corresponding (R) 4-trityloxymethyl derivative, useful as intermediate form in the synthesis of Fesoterodine and its salts, in particular for the preparation of Fesoterodine fumarate salt.

  这项发明涉及一种制备2-(3-N,N-二异丙基氨基-1-苯基丙基)-4-羟甲基苯酚及其衍生物的方法，特别是相应的(R) 4-三苯甲氧基甲基衍生物，作为费索特罗定及其盐的合成中间体形式，特别用于费索特罗定富马酸盐的制备。
• [EN] COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER<br/>[FR] POLYTHÉRAPIE IMPLIQUANT DES ANTICORPS DIRIGÉS CONTRE LA CLAUDINE 18,2 POUR LE TRAITEMENT DU CANCER
  申请人：GANYMED PHARMACEUTICALS AG

  公开号：WO2013174404A1

  公开（公告）日：2013-11-28

  The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.