3-(4-fluoro-1,2-benzoxazol-3-yl)-1H-inden-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并异恶唑
• 英文名称: 3-(4-fluoro-1,2-benzoxazol-3-yl)-1H-inden-1-ol
• 化学式: C₁₆H₁₀FNO₂
• 分子量: 267.25
• InChiKey: FMHLNYPEKLAXMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 3-O-HETEROARYL-INGENOL
  申请人：LEO LABORATORIES LIMITED

  公开号：US20150175622A1

  公开（公告）日：2015-06-25

  The present invention relates to a compound according to formula (I) wherein R 1 represents optionally substituted heteroaryl, and pharmaceutically acceptable salts, hydrates, solvates or pharmaceutically acceptable and physiologically cleavable esters thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, to methods of treatment of cosmetic indications with said compounds, and to the use of said compounds in the manufacture of medicaments.

  本发明涉及一种化合物，其化学式为（I），其中R1代表可选择取代的杂环烷基，以及药学上可接受的盐、水合物、溶剂合物或其药学上可接受和生理上可分解的酯。本发明还涉及用于制备所述化合物的中间体，用于治疗的所述化合物，包含所述化合物的药物组合物，用所述化合物治疗疾病的方法，例如与细胞增生、新生物或异形增生相关的疾病，用所述化合物治疗化妆指标的方法，以及用所述化合物制造药物的用途。
• US9422309B2
  申请人：——

  公开号：US9422309B2

  公开（公告）日：2016-08-23
• [EN] 3-O-HETEROARYL-INGENOL<br/>[FR] 3-O-HÉTÉROARYL-INGÉNOL
  申请人：LEO LAB LTD

  公开号：WO2014001215A2

  公开（公告）日：2014-01-03

  The present invention relates to a compound according to formula (I) wherein R1 represents optionally substituted heteroaryl, and pharmaceutically acceptable salts, hydrates, solvates or pharmaceutically acceptable and physiologically cleavable esters thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, to methods of treatment of cosmetic indications with said compounds, and to the use of said compounds in the manufacture of medicaments.