3-[Amino(2-methylpropyl)amino]-4-hydroxycyclobut-3-ene-1,2-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯基酰胺
• 英文名称: 3-[Amino(2-methylpropyl)amino]-4-hydroxycyclobut-3-ene-1,2-dione
• 英文别名: 3-[amino(2-methylpropyl)amino]-4-hydroxycyclobut-3-ene-1,2-dione
• 化学式: C₈H₁₂N₂O₃
• 分子量: 184.19
• InChiKey: NJIPPBQZIKYXNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] CYSTATHIONINE-Upsilon-LYASE (CSE) INHIBITORS<br/>[FR] INHIBITEURS DE LA CYSTATHIONINE- Gamma -LYASE (CSE)
  申请人：SOVA PHARMACEUTICALS INC

  公开号：WO2014018570A1

  公开（公告）日：2014-01-30

  Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine -γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.

  本文描述了一些化合物和含有这些化合物的药物组合物，这些化合物抑制半胱氨酸-γ-裂解酶（CSE）。本文还描述了使用这些CSE抑制剂的方法，单独或与其他化合物结合，用于治疗需要CSE抑制的疾病或病况。
• CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS
  申请人：SOVA PHARMACEUTICALS, INC.

  公开号：US20150266837A1

  公开（公告）日：2015-09-24

  Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.

  本文描述了一些化合物和含有这些化合物的药物组合物，这些化合物可以抑制半胱氨酸-γ-裂解酶（CSE）。本文还描述了使用这些CSE抑制剂的方法，单独或与其他化合物组合使用，用于治疗需要CSE抑制的疾病或情况。
• USE OF CSE INHIBITORS FOR THE TREATMENT OF CUTANEOUS INJURIES OR CONDITIONS AND SLEEP-RELATED BREATHING DISORDERS
  申请人：SOVA PHARMACEUTICALS, INC.

  公开号：US20150272934A1

  公开（公告）日：2015-10-01

  Described are methods of treatment of cutaneous injuries or conditions comprising administration of CSE inhibitors to individuals in need thereof. Also described herein are methods of treatment of sleep-related breathing disorders comprising administration of CSE inhibitors to individuals in need thereof.

  本文描述了治疗皮肤损伤或疾病的方法，包括向需要此类治疗的个体投药CSE抑制剂。此外，本文还描述了治疗睡眠相关呼吸障碍的方法，包括向需要此类治疗的个体投药CSE抑制剂。
• [EN] USE OF CSE INHIBITORS FOR THE TREATMENT OF CUTANEOUS INJURIES OR CONDITIONS AND SLEEP-RELATED BREATHING DISORDERS<br/>[FR] UTILISATION D'INHIBITEURS DE CSE POUR LE TRAITEMENT DE LÉSIONS OU D'AFFECTIONS CUTANÉES ET DE TROUBLES RESPIRATOIRES DU SOMMEIL
  申请人：SOVA PHARMACEUTICALS INC

  公开号：WO2014018571A2

  公开（公告）日：2014-01-30
• CYSTATHIONINE-(gamma)-LYASE (CSE) INHIBITORS FOR TREATING PAIN
  申请人：SOVA PHARMACEUTICALS, INC.

  公开号：US20150202186A1

  公开（公告）日：2015-07-23

  Described herein are methods for treating chemotherapy-induced peripheral neuropathy, or human immunodeficiency virus-associated sensory neuropathy, or symptoms thereof, comprising administering to an individual in need thereof a therapeutically effective amount of a cystathionine-γ-lyase (CSE) inhibitor. Also described herein are methods for using such CSE inhibitors in combination with other compounds.