N-(3-chloro-2-methylbenzyl)-N'-n-propyl-N"-prop-2-ynyl-[1,3,5]triazine-2,4,6-triamine hydrochloride | 1610534-48-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: N-(3-chloro-2-methylbenzyl)-N'-n-propyl-N"-prop-2-ynyl-[1,3,5]triazine-2,4,6-triamine hydrochloride
• 英文别名: N-(3-Chloro-2-methyl-benzyl)-N'-propyl-N''-prop-2-ynyl-[1,3,5]triazine-2,4,6-triamine hydrochloride；2-N-[(3-chloro-2-methylphenyl)methyl]-6-N-propyl-4-N-prop-2-ynyl-1,3,5-triazine-2,4,6-triamine;hydrochloride
• CAS: 1610534-48-9
• 化学式: C₁₇H₂₁ClN₆*ClH
• 分子量: 381.308
• InChiKey: WFQGUYREURWRFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  74.8
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(3-chloro-2-methylbenzyl)-N'-n-propyl-N"-prop-2-ynyl-[1,3,5]triazine-2,4,6-triamine 、 hydrochloric acid diethyl ether 、 O-tert-butyl-N-(4-n-propylamino-6-prop-2-ynylamino[1,3,5]triazin-2-yl)hydroxylamine hydrochloride 以to yield N-(3-chloro-2-methyl-benzyl)-N′-n-propyl-N″-prop-2-ynyl-[1,3,5]triazine-2,4,6-triamine hydrochloride (109a) in quantitative yield的产率得到N-(3-chloro-2-methylbenzyl)-N'-n-propyl-N"-prop-2-ynyl-[1,3,5]triazine-2,4,6-triamine hydrochloride
  参考文献：
  名称：

  NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME

  摘要：

  本发明包括用于预防和/或治疗呼吸控制疾病或疾病的组合物，适用于需要此类治疗的受试者。本发明还包括一种预防和/或治疗受试者呼吸系统疾病或疾病的方法，包括向受试者施用本发明的治疗有效量的组合物。本发明还包括一种预防不稳定或稳定受试者呼吸节律的方法，包括向受试者施用本发明的治疗有效量的组合物。

  公开号：

  US20150291597A1

文献信息

• [EN] NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME<br/>[FR] NOUVEAUX COMPOSÉS DE MODULATION DE RÉGULATION DE LA RESPIRATION ORALEMENT BIODISPONIBLES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：GALLEON PHARMACEUTICALS INC

  公开号：WO2014078575A2

  公开（公告）日：2014-05-22

  The present invention includes compositions that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention.
• NOVEL ORALLY BIOAVAILABLE BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF USING SAME
  申请人：Galleon Pharmaceuticals, Inc.

  公开号：US20150291597A1

  公开（公告）日：2015-10-15

  The present invention includes compositions that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition of the invention.

  本发明包括用于预防和/或治疗呼吸控制疾病或疾病的组合物，适用于需要此类治疗的受试者。本发明还包括一种预防和/或治疗受试者呼吸系统疾病或疾病的方法，包括向受试者施用本发明的治疗有效量的组合物。本发明还包括一种预防不稳定或稳定受试者呼吸节律的方法，包括向受试者施用本发明的治疗有效量的组合物。