Pyrazino<2',3':4,5>thieno<3,2-d>pyrimidin-4(3H)-on | 56881-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: Pyrazino<2',3':4,5>thieno<3,2-d>pyrimidin-4(3H)-on
• 英文别名: 3H-pyrazino[2',3':4,5]thieno[3,2-d]pyrimidin-4-one；8-Thia-3,5,10,13-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one；8-thia-3,5,10,13-tetrazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
• CAS: 56881-22-2
• 化学式: C₈H₄N₄OS
• 分子量: 204.212
• InChiKey: WMCSHHSMJOILSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Pyrazino<2',3':4,5>thieno<3,2-d>pyrimidin-4(3H)-on 、 三氯氧磷 以70%的产率得到
  参考文献：
  名称：

  SCHNELLER S. W.; CLOUGH F. W., J. HETEROCYCL. CHEM. , 1975, 12, NO 3, 513-516

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-3-氰基吡嗪 在 sodium carbonate 作用下， 以 乙醇 为溶剂， 生成 Pyrazino<2',3':4,5>thieno<3,2-d>pyrimidin-4(3H)-on
  参考文献：
  名称：

  Schneller,S.W.; Clough,F.W., Journal of Heterocyclic Chemistry, 1975, vol. 12, p. 513 - 516

  摘要：

  DOI：

文献信息

• mGluR1 antagonists as therapeutic agents
  申请人：Matasi J. Julius

  公开号：US20060009477A1

  公开（公告）日：2006-01-12

  In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J 1 -J 4 , X, and R 1 —R 5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

  在其多种实施方式中，本发明提供了式I的三环化合物（其中J1-J4、X和R1—R5如本文所定义）作为代谢型谷氨酸受体（mGluR）拮抗剂，特别是作为选择性代谢型谷氨酸受体1拮抗剂，含有该化合物的药物组合物，以及使用该化合物和组合物治疗与代谢型谷氨酸受体（例如mGluR1）相关的疾病的方法，例如疼痛、偏头痛、焦虑、尿失禁和阿尔茨海默病等神经退行性疾病。
• mGluR1 Antagonists as therapeutic agents
  申请人：Matasi J. Julius

  公开号：US20060167029A1

  公开（公告）日：2006-07-27

  In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J 1 -J 4 , X, and R 1 -R 5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

  在许多实施方案中，本发明提供了式 I 的三环化合物（其中 J 1 -J 4 、X 和 R 1 -R 5 如本文所定义）作为代谢型谷氨酸受体（mGluR）拮抗剂，特别是作为选择性代谢型谷氨酸受体 1 拮抗剂，含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗与代谢型谷氨酸受体（如 mGluR1）相关疾病（如疼痛、偏头痛、焦虑、尿失禁和神经退行性疾病，如阿尔茨海默病）的方法。
• TRICYCLIC COMPOUNDS AND THEIR USE AS MGLUR1 ANTAGONISTS
  申请人：Schering Corporation

  公开号：EP1765829B1

  公开（公告）日：2010-07-07
• MGLUR1 ANATGONISTS AS THERAPEUTIC AGENTS
  申请人：Schering Corporation

  公开号：EP1966220A2

  公开（公告）日：2008-09-10
• mGluR1 Antagonists as Therapeutic Agents
  申请人：Matasi Julius J.

  公开号：US20090082336A1

  公开（公告）日：2009-03-26

  In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J 1 -J 4 , X, and R 1 -R 5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.