Propanamide, 2-methyl-N-[2-methyl-4-[(2-methylphenyl)azo]phenyl]- | 860086-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: Propanamide, 2-methyl-N-[2-methyl-4-[(2-methylphenyl)azo]phenyl]-
• 英文别名: 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]propanamide
• CAS: 860086-78-8
• 化学式: C₁₈H₂₁N₃O
• 分子量: 295.4
• InChiKey: YRDCCJUJIWESLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  53.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compound having activity for inhibiting dioxin toxicity, pharmaceutical composition comprising the compound and method for treating disease resulting from dioxin toxicity using the compound
  申请人：Suh Ghill Pann

  公开号：US20070032458A1

  公开（公告）日：2007-02-08

  Provided are a compound having an activity for inhibiting dioxin toxicity, a pharmaceutical composition including the compound and a method of treating disease resulting from dioxin toxicity using the compound. More particularly, the compound is represented by formula 1: where, R 1 may be a hydrogen atom, a C1-C5 alkyl group or an alkylketone group; and R 2 may be a hydrogen atom, a C1-C10 alkyl group or —COR 3 , wherein R3 may be a C1-C5 alkyl group, a C1-C5 alkylamide group, a C3-C12 aryl group or a heteroaryl group. A compound having an activity for inhibiting dioxin toxicity by directly antagonizing a dioxin receptor and specifically lessening dioxin-associated toxicity without an adverse effect resulting from an overdose of the compound or an outbreak of another disease can be obtained.