4-Methylidene-5-propan-2-yl-1,3,5-triazin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-Methylidene-5-propan-2-yl-1,3,5-triazin-2-amine
• 英文别名: 4-methylidene-5-propan-2-yl-1,3,5-triazin-2-amine
• 化学式: C₇H₁₂N₄
• 分子量: 152.2
• InChiKey: RFHNFOBWNFRYIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Nucleotides for the treatment of liver cancer
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US10030044B2

  公开（公告）日：2018-07-24

  Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents. In certain embodiments, the compounds are nucleoside analogs of Formula I: (I); or a pharmaceutically acceptable salt thereof, wherein Base, Z1, Z2, Z3, Z4, V, W, X, Ar, R1 and R2 are as described herein.

  本文提供了用于治疗肝癌（如肝细胞癌、胆管癌或胆道癌）的化合物、组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，可单独或与其他抗癌剂联合使用。 在某些实施方案中，所述化合物为式I的核苷类似物：(I)；或其药学上可接受的盐，其中Base、Z1、Z2、Z3、Z4、V、W、X、Ar、R1和R2如本文所述。
• 4'-FLUORO NUCLOSIDES FOR THE TREATMENT OF HCV
  申请人：IDENIX PHARMACEUTICALS, INC.

  公开号：US20140178338A1

  公开（公告）日：2014-06-26

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are according to Formula 1501: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, PD, R A , R B , R C , L, M and Z are as described herein.
• 3'-DEOXY NUCLEOSIDES FOR THE TREATMENT OF HCV
  申请人：Idenix Pharmaceuticals, Inc.

  公开号：US20140248241A1

  公开（公告）日：2014-09-04

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-deoxy nucleoside compounds according to Formula 3001a or 3001b: or a pharmaceutically acceptable salts, solvates, stereoisomeric forms, tautomeric forms, or polymorphic forms thereof, wherein PD, Base 1 and Base 2 are as provided herein.
• NUCLEOTIDES FOR THE TREATMENT OF LIVER CANCER
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US20170029456A1

  公开（公告）日：2017-02-02

  Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents. In certain embodiments, the compounds are nucleoside analogs of Formula I: (I); or a pharmaceutically acceptable salt thereof, wherein Base, Z 1 , Z 2 , Z 3 , Z 4 , V, W, X, Ar, R 1 and R 2 are as described herein.
• NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF CANCER
  申请人：Dousson Cyril

  公开号：US20170101431A1

  公开（公告）日：2017-04-13

  Provided herein are compounds, compositions, and methods for the treatment of cancer, including leukemia. In one embodiment, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.