4-N-[2-(4-chlorophenyl)ethyl]-6-methyl-2-N-propan-2-yl-1,3,5-triazine-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-N-[2-(4-chlorophenyl)ethyl]-6-methyl-2-N-propan-2-yl-1,3,5-triazine-2,4-diamine
• 化学式: C₁₅H₂₀ClN₅
• 分子量: 305.8
• InChiKey: KJPSUAYTSCFZKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  62.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compositions and Methods for Treating Metabolic Disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US20140193498A1

  公开（公告）日：2014-07-10

  Compositions and methods for improving the pharmacokinetics and reducing the risk of adverse events resulting from biguanide compound administration are provided, comprising administering delayed release formulations of such compounds having a lag phase release.

  本发明提供了用于改善双胍类化合物的药代动力学并减少由其使用导致的不良事件风险的组合物和方法，包括给予延迟释放配方的这种化合物，其具有滞后释放阶段。
• US20140341986A1
  申请人：——

  公开号：US20140341986A1

  公开（公告）日：2014-11-20
• Biguanide Compositions and Methods of Treating Metabolic Disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US20170209394A1

  公开（公告）日：2017-07-27

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS
  申请人：Anji Pharma (US) LLC

  公开号：US20220151957A1

  公开（公告）日：2022-05-19

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
• US9481642B2
  申请人：——

  公开号：US9481642B2

  公开（公告）日：2016-11-01