3-[[(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-[1-[bis(4-methoxyphenyl)-phenylmethoxy]-2-oxopropyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl]oxymethoxymethoxy]propanenitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3-[[(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-[1-[bis(4-methoxyphenyl)-phenylmethoxy]-2-oxopropyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl]oxymethoxymethoxy]propanenitrile
• 化学式: C₄₇H₅₇N₈O₁₀P
• 分子量: 925.0
• InChiKey: SXRWKHQQIXANDB-WSVJKPHKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  66
• 可旋转键数：
  25
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  221
• 氢给体数：
  1
• 氢受体数：
  17

文献信息

• GLYCOSIDE COMPOUND, METHOD FOR PRODUCING THIOETHER, ETHER, METHOD FOR PRODUCING ETHER, METHOD FOR PRODUCING GLYCOSIDE COMPOUND, METHOD FOR PRODUCING NUCLEIC ACID
  申请人：Aoki Eriko

  公开号：US20140206856A1

  公开（公告）日：2014-07-24

  The invention provides a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at low cost and can produce a nucleic acid in high yield and with high purity. The glycoside compound has the formula wherein B, R 1 , R 2 , and R 3 are as described herein.

  本发明提供了一种葡萄糖苷化合物，能够提供一种磷酰胺酰化物，该磷酰胺酰化物能够以低成本生产，并且能够高产高纯度地产生核酸。该葡萄糖苷化合物具有以下式子：其中B，R1，R2和R3如本文所述。
• METHOD FOR PRODUCING GLYCOSIDE COMPOUNDS
  申请人：BONAC CORPORATION

  公开号：EP3301103A1

  公开（公告）日：2018-04-04

  The present invention provides a production method of the glycoside compound represented by the formula (I) or a salt thereof, which includes a step of subjecting a thioether compound represented by the formula (103) and an alcohol compound represented by the formula (105) to a coupling reaction in the presence of a halogenating agent, a desiccant and a Lewis acid, and then distillation in the presence of at least one kind of additive selected from a sulfur-containing antioxidant and a maleimide group-containing compound to give a thioether compound represented by the formula (104) (Step 0); and a step of subjecting a glycoside compound represented by the formula (Ia) and a thioether compound represented by the formula (104) to a coupling reaction in the presence of a halogenating agent, a desiccant and a Lewis acid to give a glycoside compound represented by the formula (Ib) (Step 1). By this method, a phosphoramidite preferable for the production (synthesis) of a nucleic acid can be produced more efficiently at a high purity (each compound is as defined in the DESCRIPTION).

  本发明提供了一种式(I)代表的苷化合物或其盐的生产方法，该方法包括以下步骤：在卤化剂、干燥剂和路易斯酸存在下，将式(103)代表的硫醚化合物和式(105)代表的醇化合物进行偶联反应、干燥剂和路易斯酸的存在下进行偶联反应，然后在至少一种选自含硫抗氧化剂和含马来酰亚胺基团化合物的添加剂存在下进行蒸馏，得到式（104）代表的硫醚化合物（步骤 0）；和 在卤化剂、干燥剂和路易斯酸存在下，将式（Ia）代表的苷化合物和式（104）代表的硫醚化合物进行偶联反应，得到式（Ib）代表的苷化合物（步骤 1）。通过这种方法，可以更高效、高纯度地生产（合成）核酸所需的亚磷酰胺（每种化合物的定义见 DESCRIPTION）。
• US9481702B2
  申请人：——

  公开号：US9481702B2

  公开（公告）日：2016-11-01