2-(2-Tritylaminothiazol-4-yl)-2-(methoxyimino)-essigsaeureethylester | 66215-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-(2-Tritylaminothiazol-4-yl)-2-(methoxyimino)-essigsaeureethylester
• 英文别名: Ethyl 2-methoxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetate
• CAS: 66215-70-1
• 化学式: C₂₇H₂₅N₃O₃S
• 分子量: 471.58
• InChiKey: HZUYVNWQSAISMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  三乙胺 、 2-(2-氨基噻唑-4-基)-2-甲氧亚氨基乙酸乙酯 、 三苯基氯甲烷 在 水 、 甲醇 、 乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以to obtain 6.15 g of ethyl 2-(2-tritylamino-4-thiazolyl)-2-methoxyiminoacetate melting at 120° C.的产率得到2-(2-Tritylaminothiazol-4-yl)-2-(methoxyimino)-essigsaeureethylester
  参考文献：
  名称：

  Novel 3-acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives

  摘要：

  化合物的公式为##STR1##其中R从氢和易于通过酸水解或氢解除去的基团中选择，R'从1至4个碳原子的烷基，2至4个碳原子的烯基和炔基以及易于通过酸水解或氢解除去的基团中选择，A从氢，碱金属和碱土金属或镁的等效物以及有机胺碱基中选择，但当R'为易于通过酸水解或氢解除去的基团时，R也是如此，当R'为氢时，R也是氢，波浪线表示OR'基团可以处于两种可能的同步或反向位置，具有抗生素活性和制备它们的过程。

  公开号：

  US04376203A1

文献信息

• 3-Acetoxymethyl-7-(iminoacetamido)-cephalosporanic acid derivatives
  申请人：Roussel Uclaf

  公开号：US04152432A1

  公开（公告）日：1979-05-01

  Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups easily removable by acid hydrolysis or hydrogenolysis, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal or magnesium and an organic amine base with the proviso that when R' is a group easily removable by acid hydrolysis or hydrogenolysis, R is also and when R' is hydrogen, R also is hydrogen and the wavy line means the OR' group may be in either one of the two possible syn or anti positions having antibiotic activity and process for their preparation.

  化合物的公式为：##STR1## 其中R选自氢和易于通过酸水解或氢解去除的基团，R'选自1至4个碳原子的烷基、2至4个碳原子的烯基和炔基以及易于通过酸水解或氢解去除的基团，A选自氢、碱金属和碱土金属或镁的等效物以及有机胺碱，但当R'是易于通过酸水解或氢解去除的基团时，R也是如此；当R'是氢时，R也是氢。其中波浪线表示OR'基团可以处于两种可能的同步或反向位置。该化合物具有抗生素活性，以及其制备方法。
• Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids
  申请人：Uclaf; Roussel

  公开号：US04396618A1

  公开（公告）日：1983-08-02

  Novel alkyloximes of 7-amino-thiazolyl-acetamide-cephalosporanic acids of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and --CH.sub.2 --SR', R' is selected from the group consisting of acyl of an alkanoic acid of 2 to 4 carbon atoms, 1-methyl-tetrazolyl and 2-methyl-1,3,4-thiadiazolyl, R.sub.1 is selected from the group consisting of hydrogen and a group easily removeable by acid hydrolysis or hydrogenolysis, R.sub.2 is selected from the group consisting of alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, A is selected from the group consisting of hydrogen, an alkali metal cation, an equivalent of an alkaline earth metal or magnesium, an organic amine base cation and an ester group easily removeable by acid hydrolysis or hydrogenolysis with the proviso that when R.sub.1 is hydrogen, A is not an ester group easily removeable by hydrogenolysis or acid hydrolysis and the wavy line means that OR.sub.2 is in one or the other of the two possible syn or anti isomeric positions having a very good antibiotic activity and novel processes and intermediates for their preparation.

  7-氨基噻唑基乙酰胺头孢菌素酸的新型烷氧基肟化合物，化学式如下：其中R选自由1到5个碳原子的烷基、3到5个碳原子的环烷基和--CH.sub.2 --SR'，R'选自由2到4个碳原子的脂肪酸酰基、1-甲基四唑基和2-甲基-1,3,4-噻二唑基，R.sub.1选自氢和易于通过酸水解或氢解去除的基团，R.sub.2选自由1到4个碳原子的烷基和2到4个碳原子的烯基和炔基，A选自氢、碱金属阳离子、碱土金属或镁的等价物、有机胺碱基阳离子和易于通过酸水解或氢解去除的酯基团，但当R.sub.1为氢时，A不是易于通过氢解或酸水解去除的酯基团。其中波浪线表示OR.sub.2在两种可能的同构或反异构位置之一。该化合物具有很好的抗生素活性，并且提供了其制备的新方法和中间体。
• 3-Acetoxymethyl-7-(hydroxyiminoacetamido)-cephalosporanic acid
  申请人：Roussel Uclaf

  公开号：US04283396A1

  公开（公告）日：1981-08-11

  Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups easily removable by acid hydrolysis or hydrogenolysis, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal or magnesium and an organic amine base with the proviso that when R' is a group easily removable by acid hydrolysis or hydrogenolysis, R is also and when R' is hydrogen, R also is hydrogen and the wavy line means the OR' group may be in either one of the two possible syn or anti positions having antibiotic activity and process for their preparation.

  化合物的公式为##STR1##其中R是从氢和易于通过酸水解或氢解去除的基团中选择的，R'是从1到4个碳原子的烷基，2到4个碳原子的烯基和炔基以及易于通过酸水解或氢解去除的基团中选择的，A是从氢，碱金属和等价的碱土金属或镁以及有机胺基中选择的，但是当R'是易于通过酸水解或氢解去除的基团时，R也是如此，当R'是氢时，R也是氢，波浪线表示OR'基团可以位于两个可能的同步或反向位置中具有抗生素活性及其制备方法。
• Aminothiazolyl acetic acid derivatives
  申请人：Roussel Uclaf

  公开号：US04843164A1

  公开（公告）日：1989-06-27

  Compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and groups easily removable by acid hydrolysis or hydrogenolysis, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl and alkynyl of 2 to 4 carbon atoms and groups easily removable by acid hydrolysis or hydrogenolysis, A is selected from the group consisting of hydrogen, alkali metal and equivalents of an alkaline earth metal or magnesium and an organic amine base with the proviso that when R' is a group easily removable by acid hydrolysis or hydrogenolysis, R is also and when R' is hydrogen, R also is hydrogen and the wavy line means the OR' group may be in either one of the two possible syn or anti positions having antibiotic activity and process for their preparation.

  化合物的公式为##STR1##其中R选自氢和易于通过酸水解或氢解去除的基团，R'选自1至4个碳原子的烷基，2至4个碳原子的烯基和炔基以及易于通过酸水解或氢解去除的基团，A选自氢，碱金属和等量的碱土金属或镁以及有机胺碱，但当R'为易于通过酸水解或氢解去除的基团时，R也是如此，当R'为氢时，R也是氢，而波浪线表示OR'基团可以处于两种可能的同步或反式位置，具有抗生素活性和制备它们的过程。
• 3-acetoxymethyl-7-(iminoacetamideo)-cephalosporanic acid
  申请人：Roussel UCLAF

  公开号：US05336776A1

  公开（公告）日：1994-08-09

  Thiazole intermediates for Cephalosporing are prepared.

  制备头孢菌素的噻唑中间体。