3'-Deoxy-6-azathymidine | 129454-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 3'-Deoxy-6-azathymidine
• 英文别名: 2-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-6-methyl-1,2,4-triazine-3,5-dione
• CAS: 129454-21-3
• 化学式: C₉H₁₃N₃O₄
• 分子量: 227.22
• InChiKey: OPMYUIBNAPLLAM-NKWVEPMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  91.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2',3'-Didehydro-3'-deoxy-6-azathymidine 生成 3'-Deoxy-6-azathymidine
  参考文献：
  名称：

  LIN, TAI-SHUN;YANG, JING-HUA;GAO, YOU-SONG, NUCLEOSIDES AND NUCLEOTIDES , 9,(1990) N, C. 97-108

  摘要：

  DOI：

文献信息

• LIN, TAI-SHUN;YANG, JING-HUA;GAO, YOU-SONG, NUCLEOSIDES AND NUCLEOTIDES , 9,(1990) N, C. 97-108
  作者：LIN, TAI-SHUN、YANG, JING-HUA、GAO, YOU-SONG

  DOI：——

  日期：——
• PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS
  申请人：University Of Georgia Research Foundation, Inc.

  公开号：EP2509949A2

  公开（公告）日：2012-10-17
• [EN] PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS<br/>[FR] PYRIDINONE HYDROXYCYCLOPENTYLCARBOXAMIDES : INHIBITEURS DE L'INTÉGRASE DU VIH AYANT DES APPLICATIONS THÉRAPEUTIQUES
  申请人：UNIV GEORGIA

  公开号：WO2011071849A2

  公开（公告）日：2011-06-16

  New chiral and achiral oxy- substituted cyclopentyl pyridinone diketocarboxamides and their derivatives and methods for their preparations are disclosed. The compounds include tautomers, regioisomers and geometric isomers. These complex carboxamides are designed as inhibitors of HIV replication through inhibition of HIV integrase. The compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents, especially other anti- HIV compounds (including other anti-HTV integrase agents), which can be used to create combination anti-HIV cocktails. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.