O-[(2R,4R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyl-2-(trityloxymethyl)oxolan-3-yl] imidazole-1-carbothioate

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: O-[(2R,4R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-4-methyl-2-(trityloxymethyl)oxolan-3-yl] imidazole-1-carbothioate
• 化学式: C₃₃H₂₉FN₄O₅S
• 分子量: 612.7
• InChiKey: FUKFWRDHEQABBP-DLAWUUKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 3'-DEOXY NUCLEOSIDES FOR THE TREATMENT OF HCV
  申请人：Idenix Pharmaceuticals, Inc.

  公开号：US20140248241A1

  公开（公告）日：2014-09-04

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-deoxy nucleoside compounds according to Formula 3001a or 3001b: or a pharmaceutically acceptable salts, solvates, stereoisomeric forms, tautomeric forms, or polymorphic forms thereof, wherein PD, Base 1 and Base 2 are as provided herein.
• US9309275B2
  申请人：——

  公开号：US9309275B2

  公开（公告）日：2016-04-12