1-(2-Hydroxy-3-trityloxypropyl)-4-[methoxy(trityl)amino]pyrimidin-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-(2-Hydroxy-3-trityloxypropyl)-4-[methoxy(trityl)amino]pyrimidin-2-one
• 英文别名: 1-(2-hydroxy-3-trityloxypropyl)-4-[methoxy(trityl)amino]pyrimidin-2-one
• 化学式: C₄₆H₄₁N₃O₄
• 分子量: 699.8
• InChiKey: TUWRBZMCBPWVMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  53
• 可旋转键数：
  14
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  74.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
  申请人：The Regents of the University of California

  公开号：US20170002033A1

  公开（公告）日：2017-01-05

  The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

  本公开涉及用于治疗病毒性疾病和癌症的组合物和方法，其中包括脂溶性抗病毒和抗癌无环核苷酸膦酸二酯，其制备方法以及使用这些化合物治疗病毒性疾病和癌症的方法。
• ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS FOR USE IN TREATING HUMAN PAPILLOMA VIRUS, CERVICAL INTRAEPITHELIAL NEOPLASIA, ANAL INTRAEPITHELIAL NEOPLASIA, OR VULVAR INTRAEPITHELIAL NEOPLASIA
  申请人：The Regents of the University of California

  公开号：EP3401320A1

  公开（公告）日：2018-11-14

  The present disclosure relates, inter alia, to a compound of Formula (la): or a pharmaceutically acceptable salt thereof for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia to a subject in need thereof wherein: BNuc(a) is selected from the group consisting of: La is an unsubstituted C13-29 heteroalkyl; Ra is selected from the group consisting of an unsubstituted C1-6 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl(C1-6 alkyl), a substituted or unsubstituted heteroaryl(C1-6 alkyl) and a substituted or unsubstituted heterocycloalkyl(C1-6alkyl); Xa is hydrogen, an unsubstituted C1-6alkyl, a halogen substituted C1-6alkyl, a hydroxy substituted C1-6 alkyl or an unsubstituted C1-6 alkoxy; wherein alkyl is fully saturated; and wherein the substituent is selected from the following moieties: -OH, -NH2, -SH, -CN, -CF3, -NO2, oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.

  本公开尤其涉及一种式（la）化合物： 或其药学上可接受的盐，用于治疗人乳头状瘤病毒、宫颈上皮内瘤变、肛门上皮内瘤变或外阴上皮内瘤变给需要的受试者，其中： BNuc(a)选自由以下组成的组 La 是未取代的 C13-29 杂烷基； Ra选自由未取代的C1-6烷基、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的杂环烷基、取代或未取代的芳基(C1-6烷基)、取代或未取代的杂芳基(C1-6烷基)和取代或未取代的杂环烷基(C1-6烷基)组成的组； Xa 是氢、未取代的 C1-6 烷基、卤素取代的 C1-6 烷基、羟基取代的 C1-6 烷基或未取代的 C1-6 烷氧基； 其中烷基是完全饱和的；以及 其中取代基选自以下分子：-OH、-NH2、-SH、-CN、-CF3、-NO2、氧代、卤素、未取代的烷基、未取代的杂烷基、未取代的环烷基、未取代的杂环烷基、未取代的芳基和未取代的杂芳基。
• Acyclic nucleoside phosphonate diesters
  申请人：The Regents of the University of California

  公开号：US10076533B2

  公开（公告）日：2018-09-18

  The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

  本公开主要涉及治疗病毒性疾病和癌症的组合物和方法。本发明公开了亲脂性抗病毒和抗癌无环核苷膦酸二酯、其制备方法以及使用该化合物治疗病毒性疾病和癌症的方法。
• US20140275532A1
  申请人：——

  公开号：US20140275532A1

  公开（公告）日：2014-09-18
• US20140274959A1
  申请人：——

  公开号：US20140274959A1

  公开（公告）日：2014-09-18