1-(5-Aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione | 35959-38-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 2 '，5'-二脱氧核苷
• 英文名称: 1-(5-Aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
• 英文别名: 1-[5-(aminomethyl)-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
• CAS: 35959-38-7
• 化学式: C₉H₁₃N₃O₄
• 分子量: 227.22
• InChiKey: ABYZQSMQSHNEMQ-UHFFFAOYSA-N

物化性质

• 密度：
  1.466±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Dutpase Inhibitors
  申请人：Gilbert Ian

  公开号：US20080300216A1

  公开（公告）日：2008-12-04

  Deoxyuridine derivatives of Formula (I′); where A is O, S or CH 2 ; B is O, S or CHR 3 ; R 1 is H, or various substituents; R 2 is H, F; R 3 is H, F, OH, NH 2 ; or R 2 and R 3 together form a chemical bond; D is —NHCO—, —CONH—, —O—, —C(═O)—, —CH═CH, —C≡C—, —NR 5 —; R 4 is hydrogen or various substituents; R 5 is H, C 1 -C 4 alkyl, C 1 -C 4 alkanoyl; E is Si or C; R 6 , R 7 and R 8 are independently selected from C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or a stable monocyclic, bicyclic or tricyclic ring system have utility in the prophylaxis of treatment of parasitic diseases such as malaria.

  化合物（I'）的脱氧尿嘧啶衍生物；其中A为O、S或CH2；B为O、S或CHR3；R1为H或各种取代基；R2为H、F；R3为H、F、OH、NH2；或R2和R3共同形成化学键；D为-NHCO-、-CONH-、-O-、-C（═O）-、-CH═CH、-C≡C-、-NR5-；R4为氢或各种取代基；R5为H、C1-C4烷基、C1-C4酰基；E为Si或C；R6、R7和R8分别选择自C1-C8烷基、C2-C8烯基、C2-C8炔基或稳定的单环、双环或三环环系统，在预防或治疗疟疾等寄生虫病方面具有用途。
• DUTPASE INHIBITORS
  申请人：Gilbert Ian

  公开号：US20100075924A1

  公开（公告）日：2010-03-25

  Deoxyuridine derivatives of the formula where A is O, S or CH 2 ; B is O, S or CHR 3 ; R 1 is H, or various substituents; R 2 is H, F; R 3 is H, F, OH, NH 2 ; or R 2 and R 3 together form a chemical bond; D is —NHCO—, —CONH—, —O—, —C(═O)—, —CH═CH, —C ═ C—, —NR 5 —; R 4 is hydrogen or various substituents; R 5 is H, C 1 -C 4 alkyl, C 1 -C 4 alkanoyl; E is Si or C; R 6 , R 7 and R 8 are independently selected from C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, or a stable monocyclic, bicyclic or tricyclic ring system have utility in the prophylaxis o treatment of parasitic diseases such as malaria

  Deoxyuridine衍生物的公式为： 其中A为O、S或CH2；B为O、S或CHR3；R1为H或各种取代基；R2为H、F；R3为H、F、OH、NH2；或R2和R3共同形成化学键；D为—NHCO—、—CONH—、—O—、—C(═O)—、—CH═CH、—C═C—、—NR5—；R4为氢或各种取代基；R5为H、C1-C4烷基、C1-C4酰基；E为Si或C；R6、R7和R8分别选自C1-C8烷基、C2-C8烯基、C2-C8炔基或稳定的单环、双环或三环环系统。 具有预防或治疗疟疾等寄生虫病的功效。
• US7601702B2
  申请人：——

  公开号：US7601702B2

  公开（公告）日：2009-10-13