benzoic acid-(4-octyl-phenyl ester) | 89202-50-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: benzoic acid-(4-octyl-phenyl ester)
• 英文别名: Benzoesaeure-(4-octyl-phenylester)；(4-Octylphenyl) benzoate
• CAS: 89202-50-6
• 化学式: C₂₁H₂₆O₂
• 分子量: 310.436
• InChiKey: LLHITUVSWAXSSA-UHFFFAOYSA-N

物化性质

• 沸点：
  426.0±24.0 °C(Predicted)
• 密度：
  1.018±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  辛酰氯 在 盐酸 、 三氯化铝 、 amalgamated zinc 、 溶剂黄146 作用下， 生成 benzoic acid-(4-octyl-phenyl ester)
  参考文献：
  名称：

  Pigment epithelial detachment in the elderly

  摘要：

  Background: A prospective analysis was performed to characterize the angiographic appearance, natural course and prognosis of serous pigment epithelial detachments (PEDs) in elderly patients. The aim was to differentiate PEDs according to their angiographic characteristics and to analyze the specific clinical, visual and morphologic course of the different PEDs. Methods: Fluorescein and indocyanine green angiography were performed in 10 1 consecutive patients (53-87 years; 63 female, 38 male) with clinical signs of serous PED and drusen. Results: Different types of serous PED were identified: polypoidal choroidal vasculopathy (PCV)-associated PED in 14 patients (13.9%), vascular PED in 72 (71.2%), and avascular PED in 15 (14.9%). All PEDs resulted initially in similar visual loss. Avascular PEDs were smaller than vascular PEDs, and the latter were smaller than PCV-PEDs. During follow-up these differences were always present, but all PEDs enlarged initially followed by regression. This course was associated in all PEDs with progressive visual loss, accompanied by the development of RPE atrophy in avascular PEDs or disciform scars or RPE tears in the two other types. Conclusion: Despite different associations, all PEDs have a similar clinical course with respect to visual loss and enlargement or regression. This is compatible with the proposed common pathogenetic background with a hydrophobic barrier in Bruch's membrane causing fluid resulting from RPE pumping activity to accumulate between the pigment epithelium and Bruch's membrane.

  DOI：

  10.1007/s00417-002-0505-8

文献信息

• HOLOGRAPHIC FLAKE PIGMENT
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0728329B1

  公开（公告）日：1999-05-12
• US3981856A
  申请人：——

  公开号：US3981856A

  公开（公告）日：1976-09-21
• US4495311A
  申请人：——

  公开号：US4495311A

  公开（公告）日：1985-01-22
• US5415950A
  申请人：——

  公开号：US5415950A

  公开（公告）日：1995-05-16
• US5500310A
  申请人：——

  公开号：US5500310A

  公开（公告）日：1996-03-19