5-[4-[[4-(3-Carboxy-4-chloroanilino)phenyl]-chloro-phenylmethyl]anilino]-2-chlorobenzoic acid | 143193-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5-[4-[[4-(3-Carboxy-4-chloroanilino)phenyl]-chloro-phenylmethyl]anilino]-2-chlorobenzoic acid
• CAS: 143193-31-1
• 化学式: C₃₃H₂₃Cl₃N₂O₄
• 分子量: 617.9
• InChiKey: XBBQRUDAAHWPBS-UHFFFAOYSA-N

物化性质

• 沸点：
  783.9±60.0 °C(Predicted)
• 密度：
  1.453±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  98.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Method and Apparatus for Forming Chromonic Nanoparticles
  申请人：Tokie H. Jeffrey

  公开号：US20070128291A1

  公开（公告）日：2007-06-07

  A method and apparatus for forming guest molecules encapsulated with chromonic material are described. The method includes atomizing a solution to form a pre-atomized particle stream. The solution includes chromonic material, a guest molecule and a carrier fluid. Then, atomizing the pre-atomized particle stream to form an atomized particle stream; evaporating at least a portion of the carrier fluid from the atomized particle stream to form a dried atomized particle stream, and forming encapsulated guest molecules from the dried atomized particle stream.

  本发明涉及一种形成以色素物质封装的客体分子的方法和装置。该方法包括将溶液雾化以形成预雾化的颗粒流。该溶液包括色素物质、客体分子和载体流体。然后，将预雾化的颗粒流雾化以形成雾化的颗粒流；从雾化的颗粒流中蒸发至少一部分载体流体以形成干燥的雾化颗粒流，并从干燥的雾化颗粒流中形成封装的客体分子。
• Compositions for Encapsulation and Controlled Release
  申请人：Sahouani Hassan

  公开号：US20080063714A1

  公开（公告）日：2008-03-13

  The invention comprises compositions and methods useful for encapsulation and controlled release of guest molecules, such as drugs. Compositions of the present invention comprise a matrix comprising molecules that are non-covalently crosslinked by multi-valent cations, wherein the molecules that are non-covalently crosslinked are non-polymeric, have more than one carboxy functional group, and have at least partial aromatic or heteroaromatic character The compositions are characterized in that a guest molecule may be encapsulated within the matrix and subsequently released.

  该发明包括用于封装和控制释放客体分子（如药物）的组合物和方法。本发明的组合物包括一个基质，该基质由多价阳离子非共价交联的分子组成，其中非共价交联的分子是非聚合物，具有多于一个羧基官能团，并且具有至少部分芳香或杂环芳香性质。该组合物的特点在于，客体分子可以被封装在基质内，并随后释放。
• COMPOSITIONS FOR ENCAPSULATION AND CONTROLLED RELEASE
  申请人：3M Innovative Properties Company

  公开号：EP1651035A2

  公开（公告）日：2006-05-03
• METHOD AND APPARATUS FOR FORMING CHROMONIC NANOPARTICLES
  申请人：3M Innovative Properties Company

  公开号：EP1957190A2

  公开（公告）日：2008-08-20
• Methods Of Inhibiting Osteoclast Activity
  申请人：Greene Mark I.

  公开号：US20090306030A1

  公开（公告）日：2009-12-10

  Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteoclastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.