芒硝

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 中文名称: 芒硝
• 中文别名: 结晶硫酸钠,十水合物；格劳伯盐；结晶硫酸钠；结晶硫酸钠,十水；十水合硫酸钠；硫酸钠,十水；芒硝(95%)；芒硝矿；十水硫酸钠；晶硝
• 英文名称: disodium;sulfate;decahydrate
• 化学式: H20Na2O14S
• 分子量: 322.2
• InChiKey: RSIJVJUOQBWMIM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -15.58
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.6
• 氢给体数：
  10
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  2-氯-4,5-二氟苯甲酸甲酯 、 芒硝 在 氮气 、 silica gel 、 甲醇 、 二氯甲烷 作用下， 以 四氢呋喃 、 氢化铝锂 为溶剂， 反应 4.5h， 以to give a white solid (120, 4.20 g, 85.2%)的产率得到(2-氯-4,5-二氟-苯基)-甲醇
  参考文献：
  名称：

  COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

  摘要：

  本文描述了对蛋白激酶活性有作用的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病情的方法。

  公开号：

  US20080221148A1
• 作为产物：
  描述：

  Sodium sulfate-III 在 水 、 magnesium sulfate 作用下， 以 水 为溶剂， 以to form sodium sulfate decahydrate, or 1.27 kg water/kg sodium sulfate的产率得到芒硝
  参考文献：
  名称：

  Solid microbicidal composition

  摘要：

  一种固体杀菌组合物，包含5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮的混合物，硫酸镁，金属硝酸盐，氯化镁和水。

  公开号：

  US08197836B2
• 作为试剂：
  描述：

  Lithium aluminium hydride 、 三氯化铝 、 α-azidomethyl-N,N-diethyl-1-naphthalenemethanamine 在 氮气 、 silica gel 、 芒硝 、 二氯甲烷 、 Sodium sulfate-III 作用下， 以 乙醚 为溶剂， 生成 N¹,N¹-diethyl-1-(1-naphthalenyl)-1,2-ethanediamine
  参考文献：
  名称：

  N-(aminoalkyl)-substituted(N or C

  摘要：

  该公式化合物为N-(氨基烷基)-取代(N或C烷基)-芳基-4-(甲基磺酰氨基)苯甲酰胺，其中R为C1-C4直链烷基，R1、R2和R3中的一个为苯基或萘基，另外两个为氢，--NR4R5为二级或三级氨基基团，X和X1为氢或烷基，n为0或1，可用作抗心律失常药物，特别是作为I类/III类联合药物治疗心律失常。

  公开号：

  US04920116A1

文献信息

• Phosphocholine derivative inhibitors of phospholipase A.sub.2
  申请人：American Cyanamid Company

  公开号：US05144045A1

  公开（公告）日：1992-09-01

  Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.

  公开了具有以下式子的磷酸胆碱衍生物：##STR1## 其中W、Z、Q和R在说明书中描述，被用来抑制磷脂酶A.sub.2酶。还公开了制备和使用这些化合物的方法。
• Heat sink protective packaging for thermolabile goods
  申请人：PyMaH Corporation

  公开号：US04903493A1

  公开（公告）日：1990-02-27

  There is disclosed an improved heat sink composition and a method for preparing said composition to protect thermolabile goods from degradation or destruction from high temperatures. A representative composition includes sodium sulfate, sodium sulfate decahydrate (also known as Glauber's salt) and fumed silcon dioxide, a hydrophilic suspension agent which maintains the excess anhydrous sodium sulfate in uniform suspension when the composition is in a liquid state. In a preferred embodiment, the salt prior to use is dissolved in water, and driven to saturation, the hydrophilic agent is added, and the suspension driven to an over saturated state by the additional of from 1 to 30% anhydrous salt. The composition is then sealed in a plastic container of the desired shape to form an improved heat sink. The goods to be protected are packaged with the heat sink, whose salt hydrate has a melting point about 3.degree. C. to about 5.degree. C. lower than the thermosensitive temperature of the goods to protect them when the temperature of the environment exceeds the temperature of the goods. In the preferred embodiment, the goods and heat sink are surrounded with a layer of insulation which is adjacent to the outside container, which may be made of cardboard, paper, plastic and/or wood.

  本发明公开了一种改进的散热剂组合物和制备该组合物的方法，用于保护易受高温降解或破坏的物品。代表性组合物包括硫酸钠、十水硫酸钠（也称为格劳伯盐）和烟雾硅二氧化物，一种亲水性悬浮剂，当该组合物处于液态时，可以保持过量的无水硫酸钠均匀悬浮。在一种优选实施例中，使用前将盐溶解在水中并达到饱和状态，加入亲水性剂，并通过添加1至30％的无水盐将悬浮剂推向过饱和状态。然后将组合物密封在所需形状的塑料容器中，形成改进的散热剂。要保护的物品与散热剂一起包装，其盐水合物的熔点比要保护物品的热敏温度低约3℃至约5℃，以在环境温度超过物品温度时保护它们。在优选实施例中，物品和散热剂周围包裹着一层绝缘层，该绝缘层靠近外部容器，该外部容器可以由纸板、纸张、塑料和/或木材制成。
• Sulfonyl benzimidazole derivatives
  申请人：Kon-I Kana

  公开号：US20060094750A1

  公开（公告）日：2006-05-04

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, B, R 1 , R 2 and R 3 are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as cancer chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, GERD, constipation, diarrhea, functional gastrointestinal disorders, irritable bowel syndrome, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, COPD, cryptogenic fibrosing alveolitis and bronchitis.

  本发明涉及化合物的公式（I）或其药学上可接受的盐，其中A，B，R1，R2和R3如本文所述，并且含有这种化合物的组合物，以及在治疗由CB2受体活性介导的病症中使用这种化合物，例如但不限于炎症性疼痛，伤害性疼痛，神经病性疼痛，纤维肌痛，慢性腰痛，内脏疼痛，急性脑缺血，疼痛，慢性疼痛，急性疼痛，带状疱疹后神经痛，神经病，神经痛，糖尿病神经病，艾滋病相关神经病，神经损伤，类风湿性关节炎疼痛，骨关节炎疼痛，背痛，癌症疼痛，牙痛，纤维肌痛，神经炎，坐骨神经痛，炎症，神经退行性疾病，咳嗽，支气管收缩，肠易激综合症（IBS），炎症性肠病（IBD），结肠炎，脑血管缺血，呕吐，例如由癌症化疗引起的呕吐，类风湿性关节炎，哮喘，克罗恩病，溃疡性结肠炎，哮喘，皮炎，季节性过敏性鼻炎，GERD，便秘，腹泻，功能性胃肠障碍，肌肤T细胞淋巴瘤，多发性硬化症，骨关节炎，牛皮癣，系统性红斑狼疮，糖尿病，青光眼，骨质疏松症，肾小球肾炎，肾缺血，肾炎，肝炎，脑卒中，血管炎，心肌梗死，脑缺血，可逆性气道阻塞，成人呼吸道疾病综合症，慢性阻塞性肺病，隐源性纤维化性肺炎和支气管炎。
• Azole compounds
  申请人：Sakai Nozomu

  公开号：US20050090534A1

  公开（公告）日：2005-04-28

  The present invention provides a compound represented by the formula (I) wherein R 1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group, A is an optionally substituted cyclic amino group or —NR 2 —W-D wherein R 2 is a hydrogen atom or an alkyl group, W is a bond or a divalent acyclic hydrocarbon group, and D is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom, and Y is a bond or a divalent acyclic hydrocarbon group, or a salt thereof, which is useful for the prophylaxis or treatment of diabetic neuropathy and the like.

  本发明提供了一种化合物，其表示为公式(I)，其中R1是氢原子、卤素原子、可选取代的碳氢基团、可选取代的杂环基团、可选取代的羟基、可选取代的硫醇基或可选取代的氨基；A是可选取代的环状氨基基团或-NR2-W-D，其中R2是氢原子或烷基团，W是键或双价的无环烃基团，D是可选取代的环状基团、可选取代的氨基或可选取代的酰基团；B是可选取代的碳氢基团或可选取代的杂环基团；X是氧原子、硫原子或可选取代的氮原子；Y是键或双价的无环烃基团，或其盐。该化合物对于预防或治疗糖尿病性神经病等方面有用。
• Imidazo-pyridine derivatives as ligands for gaba receptors
  申请人：——

  公开号：US20020188000A1

  公开（公告）日：2002-12-12

  A class of 3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a —NH— linkage, are selective ligands for GABA A receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

  一类3-苯基咪唑[1,2-a]吡啶衍生物，苯环的间位取代一个可选取代芳基或杂环芳基，该芳基或杂环芳基直接连接或通过氧原子或-NH-键桥接，是选择性的GABAA受体配体，特别是对其α2和/或α3亚基具有高亲和力，因此对于治疗和/或预防中枢神经系统疾病，包括焦虑和惊厥，具有益处。

表征谱图