1,7-Dimethyl-1,7-diazaspiro<5.5>undecan | 5498-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 1,7-Dimethyl-1,7-diazaspiro<5.5>undecan
• 英文别名: 1,7-dimethyl-1,7-diaza-spiro[5.5]undecane；1,7-Dimethyl-1,7-diazaspiro[5.5]undecane
• CAS: 5498-66-8
• 化学式: C₁₁H₂₂N₂
• 分子量: 182.309
• InChiKey: IXHCNCCKKGHJSV-UHFFFAOYSA-N

物化性质

• 沸点：
  110-114 °C
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,7-Dimethyl-1,7-diazaspiro<5.5>undecan 在 platinum(IV) oxide 、 氢气 作用下， 以82%的产率得到
  参考文献：
  名称：

  1,7-Diazaspiro [5.5]十一烷-被忽略的杂环

  摘要：

  描述了通过克莱森缩合和酸催化的N -Boc-δ-戊内酰胺螺环化和螺环化的一种简便的三步合成1,7-二氮杂螺[5.5]十一烷的方法。该螺氨基缩醛与亲电试剂的反应包括烷基卤，烷烃二卤化物，酰氯和磺酰氯，得到螺环加合物或四氢吡啶衍生物。此外，母体杂环是一种新型的二齿配体，并与钌（II）和铜（II）形成配合物。

  DOI：

  10.1021/ol402301g
• 作为产物：
  描述：

  1-甲基-2-哌啶酮 在 氯苯 、 三氯氧磷 、 盐酸 作用下， 以74%的产率得到1,7-Dimethyl-1,7-diazaspiro<5.5>undecan
  参考文献：
  名称：

  1,7-Diazaspiro [5.5]十一烷-被忽略的杂环

  摘要：

  描述了通过克莱森缩合和酸催化的N -Boc-δ-戊内酰胺螺环化和螺环化的一种简便的三步合成1,7-二氮杂螺[5.5]十一烷的方法。该螺氨基缩醛与亲电试剂的反应包括烷基卤，烷烃二卤化物，酰氯和磺酰氯，得到螺环加合物或四氢吡啶衍生物。此外，母体杂环是一种新型的二齿配体，并与钌（II）和铜（II）形成配合物。

  DOI：

  10.1021/ol402301g

文献信息

• Substituted Diaza-Spiro-[5.5]-Undecane Derivaties and Their Use as Neurokinin Antagonists
  申请人：Janssens Eduard Frans

  公开号：US20070232636A1

  公开（公告）日：2007-10-04

  This invention concerns substituted diaza-spiro-[5.5]-undecane derivatives having neurokinin antagonistic activity, in particular NK 1 antagonistic activity, a combined NK 1 /NK 2 antagonistic activity, a combined NK 1 /NK 3 antagonistic activity and a combined NK 1 /NK 2 /NK 3 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, COPD and micturition disorders such as urinary incontinence. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.
• NOVEL SUBSTITUTED DIAZA-SPIRO-PYRIDINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES
  申请人：Andres-Gil Jose Ignacio

  公开号：US20100035909A1

  公开（公告）日：2010-02-11

  The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.
• US7544694B2
  申请人：——

  公开号：US7544694B2

  公开（公告）日：2009-06-09
• US8158643B2
  申请人：——

  公开号：US8158643B2

  公开（公告）日：2012-04-17
• 1,7-Diazaspiro[5.5]undecane – A Neglected Heterocycle
  作者：Jens Cordes、Philip R. D. Murray、Andrew J. P. White、Anthony G. M. Barrett

  DOI：10.1021/ol402301g

  日期：2013.10.4

  A convenient and simple three step synthesis of 1,7-diazaspiro[5.5]undecane via Claisen condensation and acid catalyzed decarboxylation and spirocyclization of N-Boc-δ-valerolactam is described. Reactions of this spiroaminal with electrophiles including alkyl halides, alkane dihalides, acid chlorides, and sulfonyl chlorides gave either spirocyclic adducts or tetrahydropyridine derivatives. Additionally

  描述了通过克莱森缩合和酸催化的N -Boc-δ-戊内酰胺螺环化和螺环化的一种简便的三步合成1,7-二氮杂螺[5.5]十一烷的方法。该螺氨基缩醛与亲电试剂的反应包括烷基卤，烷烃二卤化物，酰氯和磺酰氯，得到螺环加合物或四氢吡啶衍生物。此外，母体杂环是一种新型的二齿配体，并与钌（II）和铜（II）形成配合物。