(2-methyl-thiazolo[5,4-d]pyrimidin-7-yl)-phenyl-amine | 100841-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 1,3-噻唑并[5,4-d]嘧啶
• 英文名称: (2-methyl-thiazolo[5,4-d]pyrimidin-7-yl)-phenyl-amine
• 英文别名: 2-methyl-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-7-amine
• CAS: 100841-38-1
• 化学式: C₁₂H₁₀N₄S
• 分子量: 242.304
• InChiKey: YLQPYSMFIJCUFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-formylamino-2-methyl-thiazole-4-carboxylic acid amide 、 苯胺 以55%的产率得到
  参考文献：
  名称：

  ANDERSEN K. E.; HAMMAD M.; PEDERSEN E. B., LIEBIGS ANN. CHEM.,(1986) N 7, 1255-1261

  摘要：

  DOI：

文献信息

• Diphosphorus pentaoxide in organic synthesis, XXVII. A one-step synthesis of thiazolo[5,4-d]pyrimidin-7-amines and purine-6-thiones from 5-(acylamino)-2-methyl-4-thiazolecarboxamides
  作者：Knud Erik Andersen、Mahmoud Hammad、Erik B. Pedersen

  DOI：10.1002/jlac.198619860711

  日期：1986.7.14

  5-(Acylamino)-2-methyl-4-thiazolecarboxamides 1 have been converted into a series of N-arylthiazolo[5,4-d]pyrimidin-7-amines 2 and 9-aryl-1,9-dihydro-6H-purine-6-thiones 3 by heating in a mixture of diphosphorus pentaoxide, triethylamine hydrochloride, and an appropriate substituted aniline at 240°C for 2 min and then at 160°C for 1 h. The ratio of 2 and 3 depends on the aniline and thiazole used.

  5-（酰基氨基）-2-甲基-4-噻唑羧酰胺1已转化为一系列N-芳基噻唑并[5,4- d ]嘧啶7-胺2和9-芳基-1,9-二氢-6 H通过在五氧化二磷，三乙胺盐酸盐和适当的取代苯胺的混合物中于240°C加热2分钟，然后在160°C加热1小时，生成-嘌呤6-硫酮3。2和3的比例取决于所用的苯胺和噻唑。
• Thiazolopyrimidine Derivative
  申请人：Sugihara Yoshihiro

  公开号：US20080269238A1

  公开（公告）日：2008-10-30

  The present invention provides a compound represented by the following Formula: wherein A is an aryl group or a heteroaryl group, each of which may be substituted; R 1 is a group which is bonded through carbon; R 2 is hydrogen or an aliphatic hydrocarbon group; and X is —NR 3 —, —O—, —S—, —SO—, —SO 2 —, or —CHR 3 — (wherein R 3 is hydrogen or an aliphatic hydrocarbon group), or a salt thereof, or a prodrug thereof, which has growth factor receptor tyrosine kinase inhibitory activity and low toxicity, and is useful for prevention and treatment of cancer, and thus can be sufficiently used as a medicine.

  本发明提供了以下式子所表示的化合物：其中，A是芳基或杂芳基，每个都可以被取代；R1是通过碳键结合的基团；R2是氢或脂肪烃基团；X是-NR3-、-O-、-S-、-SO-、-SO2-或-CHR3-（其中，R3是氢或脂肪烃基团），或其盐或前药。该化合物具有生长因子受体酪氨酸激酶抑制活性和低毒性，并且对于预防和治疗癌症非常有用，因此可以充分用作药物。
• THIAZOLOPYRIMIDINE DERIVATIVE
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1731523A1

  公开（公告）日：2006-12-13

  The present invention provides a compound represented by the following Formula: wherein A is an aryl group or a heteroaryl group, each of which may be substituted; R1 is a group which is bonded through carbon; R2 is hydrogen or an aliphatic hydrocarbon group; and X is -NR3-, -O-, -S-, -SO-, -SO2-, or -CHR3-(wherein R3 is hydrogen or an aliphatic hydrocarbon group), or a salt thereof, or a prodrug thereof, which has growth factor receptor tyrosine kinase inhibitory activity and low toxicity, and is useful for prevention and treatment of cancer, and thus can be sufficiently used as a medicine.

  本发明提供了由下式表示的化合物： 其中 A 是芳基或杂芳基，每个芳基或杂芳基均可被取代；R1 是通过碳键合的基团；R2 是氢或脂肪族烃基；X为-NR3-、-O-、-S-、-SO-、-SO2-或-CHR3-（其中R3为氢或脂族烃基），或其盐，或其原药，具有生长因子受体酪氨酸激酶抑制活性和低毒性，可用于预防和治疗癌症，因此可充分用作药物。
• ANDERSEN K. E.; HAMMAD M.; PEDERSEN E. B., LIEBIGS ANN. CHEM.,(1986) N 7, 1255-1261
  作者：ANDERSEN K. E.、 HAMMAD M.、 PEDERSEN E. B.

  DOI：——

  日期：——