N-[1-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-[1-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
• 化学式: C₃₇H₃₅N₃O₇
• 分子量: 633.7
• InChiKey: MYSNCIZBPUPZMQ-AWNNHQFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  47
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS<br/>[FR] NOUVEAUX RÉACTIFS À BASE DE PHOSPHORE (V), LEURS PROCÉDÉS DE PRÉPARATION ET LEUR UTILISATION DANS LA FABRICATION DE COMPOSÉS ORGANOPHOSHOREUX (V) STÉRÉODÉFINIS
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2019200273A1

  公开（公告）日：2019-10-17

  The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

  本发明涉及新型磷（V）（P(V)）试剂，其制备方法以及利用这种新型试剂制备有机磷（V）化合物的方法。
• Novel phosphate and thiophosphate protecting groups
  申请人：——

  公开号：US20040082774A1

  公开（公告）日：2004-04-29

  Novel P(III) bisamidite reagents as phosphorus protecting groups, nucleoside phosphoramidite intermediates, and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared through the protection of one or more internucleosidic phosphorus functionalities, preferably followed by oxidation and cleavage of the protecting groups to provide oligonucleotides. Methods for preparing oligoribonucleotides are also disclosed.

  本发明揭示了Novel P(III)双酰胺试剂作为磷保护基，核苷酸磷酰胺中间体和制备它们的合成过程。此外，通过保护一个或多个核苷酸之间的磷功能基，最好是随后进行氧化和去保护基，以提供寡核苷酸，制备寡聚化合物。本发明还揭示了制备寡核糖核酸的方法。
• Chemical DNA synthesis
  申请人：MONSANTO COMPANY

  公开号：EP0090789A1

  公开（公告）日：1983-10-05

  A process for the production of oligonucleotides such as DNA is disclosed which comprises the phosphite triester method on inorganic solid support in which a hindered dialkylamino nucleoside phosphite having a total of 4 to 6 carbon atoms in the dialkyl group is employed as an intermediate reagent in the synthesis. The solid support preferably is controlled pore glass with a long spacer.

  本发明公开了一种用于生产 DNA 等寡核苷酸的工艺，该工艺包括在无机固体载体上使用亚磷酸三酯法，在合成过程中使用受阻二烷基氨基核苷亚磷酸作为中间试剂，亚磷酸二烷基共有 4 至 6 个碳原子。固体支持物最好是带有长间隔的可控孔隙玻璃。
• PROCESS FOR PRODUCING PHOSPHOROAMIDITE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1582528A1

  公开（公告）日：2005-10-05

  The present invention provides high purity phosphoroamidite products by reducing the amount of impurities of triphosphite which has been additionally produced according to the conventional technique. Phosphoroamidites can be obtained with high purity such that the excess reaction is suppressed by using a reaction activator hardly generating triphosphite. According to the present invention, phosphoroamides can be obtained with high purity, which has heretofore been difficult to suppress the generation of impurities of triphosphite.

  本发明通过减少根据传统技术额外生产的亚磷酸三磷酸盐的杂质含量，提供高纯度的亚磷酸酰胺产品。 通过使用几乎不产生亚磷酸三磷酸盐的反应活化剂，可以抑制过量反应，从而获得高纯度的亚磷酰胺。 根据本发明，可以获得高纯度的磷酰胺，而在此之前，很难抑制亚磷酸三磷酸盐杂质的产生。
• NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：EP3774824A1

  公开（公告）日：2021-02-17