1-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 化学式: C₃₁H₃₂N₂O₇
• 分子量: 544.6
• InChiKey: UBTJZUKVKGZHAD-DXISBFFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  S,S'-diphenylphosphorodithioate 、 1-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione 生成 1-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-bis(phenylsulfanyl)phosphoryloxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  XATA, TSUDZIAKI;SEHKINEH, MITSUO

  摘要：

  DOI：

文献信息

• PHOSPHORAMIDITE BUILDING BLOCKS FOR SUGAR-CONJUGATED OLIGONUCLEOTIDES
  申请人：AM CHEMICALS LLC

  公开号：US20160083414A1

  公开（公告）日：2016-03-24

  Novel nucleoside phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one phosphotriester linkage conjugated to a monosaccharide and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said building blocks, preferably followed by removal of protecting groups to provide monosaccharide-conjugated oligonucleotides.

  揭示了用于制备含至少一种磷酸三酯键连接的寡核苷酸的合成寡核苷酸的新型核苷酸磷酰胺酯构建模块，其与单糖偶联，并公开了制备这些构建模块的合成过程。此外，使用这些构建模块制备寡聚合物化合物，最好是在去除保护基之后，以提供单糖偶联的寡核苷酸。
• Antisense molecules and method of controlling expression of gene function by using the same
  申请人：——

  公开号：US20030162739A1

  公开（公告）日：2003-08-28

  An antisense molecule which acts on both directions of the inhibition and expression of a gene function and is capable of on-off switching of a gene function appropriately depending on the external factors (orientation controlling factors); and a method for reversibly controlling the expression of a gene function by using the antisense molecule. Such an antisense molecule, which has at least one sugar-base moiety consisting of sugar and a purine or pyrimidine base bonded thereto via a glucoside bond, can bind to a mRNA/gene and/or dissociate therefrom under the orientation control of the base moiety in the molecule by the orientation controlling factors.

  一种反义分子，可以作用于基因功能的抑制和表达的两个方向，并且能够根据外部因素（定向控制因子）适当地开关基因功能；以及一种通过使用该反义分子可逆地控制基因功能表达的方法。这样的反义分子至少包含一个由糖和通过葡苷键连接到糖上的嘌呤或嘧啶碱基部分，可以通过分子中碱基部分的定向控制因子的定向控制，结合到mRNA/基因上，和/或从中解离。
• Nucleoside derivatives
  申请人：——

  公开号：US20030208050A1

  公开（公告）日：2003-11-06

  Novel nucleoside derivatives represented by the following general formula (1): 1 wherein X is(are) the same or different and each represents a pyrimidine or purine base or a derivative thereof, Y-and Y′ are the same or different and each represents at least one amino acid or amino acid derivative selected from the group consisting of serine, threonine, ornithine, aspartic acid, glutamic acid, lysine, arginine, cysteine, methionine, &dgr;-hydroxylysine, N-aminoethylglycine, N-aminoethylserine, N-aminoethyllysine, N-aminoethylornithine, N-aminoethylaspartic acid, N-aminoethylglutamic acid, homoglutamic acid, &bgr;-thiocarbonylaspartic acid, &ggr;-thiocarbonylglutamic acid, and &dgr;-thiocarbonylhomoglutamic acid, R 1 represents a hydrogen atom or a hydroxyl group, A represents a single bond or a carbonyl or thiocarbonyl group, 1 is an integer of 0 to 5, and n is an integer of 1 to 100.

  以下是通用公式（1）所代表的新型核苷衍生物： 其中X是相同或不同的，每个代表嘧啶或嘌呤碱基或其衍生物，Y和Y'是相同或不同的，每个代表丝氨酸、苏氨酸、鸟氨酸、天冬氨酸、谷氨酸、赖氨酸、精氨酸、半胱氨酸、蛋氨酸、δ-羟基赖氨酸、N-氨基乙基甘氨酸、N-氨基乙基丝氨酸、N-氨基乙基赖氨酸、N-氨基乙基鸟氨酸、N-氨基乙基天冬氨酸、N-氨基乙基谷氨酸、同谷氨酸、β-硫代羰基天冬氨酸、γ-硫代羰基谷氨酸和δ-硫代羰基同谷氨酸，R1代表氢原子或羟基，A代表单键或羰基或硫代羰基，1是0到5的整数，n是1到100的整数。
• Methods of producing phosphitylated compounds
  申请人：——

  公开号：US20030232980A1

  公开（公告）日：2003-12-18

  Provided are methods of producing phosphitylated compounds, including 3′-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula I 1 wherein R, R 1 , and R 2 are independently C 1 -C 10 alkyl, C 1 -C 10 cycloalkyl, C 1 -C 10 aryl, C 1 -C 10 aralkyl, C 1 -C 10 heteroalkyl, or C 1 -C 10 heteroaryl; (2) acid-base complexes derived from an amine base of Formula II 2 wherein R 3 , R 4 , R 5 , R 6 , and R 7 are independently hydrogen, C 1 -C 10 alkyl, C 1 -C 10 cycloalkyl, C 1 -C 10 aryl, C 1 -C 10 aralkyl, C 1 -C 10 heteroalkyl, or C 1 -C 10 heteroaryl, and at least one of R 3 , R 4 , R 5 R 6 , and R 7 is not hydrogen.; (3) acid-base complexes derived from a diazabicyclo amine base; (4) zwitterionic amine complexes; and (5) combinations of two or more thereof, to produce a phosphitylated compound.

  提供了生产磷酰化化合物的方法，包括3′-O-磷酰胺酯，其中包括以下步骤：在磷酰化试剂的存在下，将含羟基化合物与磷酰化活化剂反应，所述磷酰化活化剂选自以下羧基复合物组成的羧基复合物：(1)来自式I的胺碱的酸碱复合物，其中R、R1和R2独立地为C1-C10烷基、C1-C10环烷基、C1-C10芳基、C1-C10芳基烷基、C1-C10杂原子烷基或C1-C10杂原子芳基；(2)来自式II的胺碱的酸碱复合物，其中R3、R4、R5、R6和R7独立地为氢、C1-C10烷基、C1-C10环烷基、C1-C10芳基、C1-C10芳基烷基、C1-C10杂原子烷基或C1-C10杂原子芳基，且R3、R4、R5、R6和R7中至少有一个不是氢；(3)来自二氮杂双环胺碱的酸碱复合物；(4)带电离子的胺复合物；以及(5)两者或两者以上的组合物，以产生磷酰化化合物。
• METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID
  申请人：Shiba Yoshinobu

  公开号：US20090149645A1

  公开（公告）日：2009-06-11

  A method is provided for removing a 2-cyanoethoxymethyl (CEM) group and substituting the 2′-hydroxyl group of each ribose of an oligonucleic acid derivative with good reproducibility and high efficiency.

  提供了一种方法，用于去除2-氰乙氧甲基（CEM）基团，并将寡核苷酸衍生物的每个核糖的2'-羟基以良好的可重复性和高效率进行置换。