N-[9-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-[9-[(2R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
• 化学式: C₃₅H₃₇N₅O₇
• 分子量: 639.7
• InChiKey: RMQXDNUKLIDXOS-NPQGXCPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  47
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Method for purifying 5' -protected 2' -deoxypurine nucleosides
  申请人：——

  公开号：US20030009028A1

  公开（公告）日：2003-01-09

  A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

  一种用于高效纯化5′保护的2′-去氧嘌呤核苷的方法，先前其高效生产曾经困难。通过获得含有类似腈结构的溶剂的包含晶体，可将杂质分离以纯化5′保护的2′-去氧嘌呤核苷。该发明使得在大规模上轻松合成高纯度的保护去氧嘌呤核苷成为可能，而此前通常通过柱层析法进行。
• Novel phosphate and thiophosphate protecting groups
  申请人：——

  公开号：US20040082774A1

  公开（公告）日：2004-04-29

  Novel P(III) bisamidite reagents as phosphorus protecting groups, nucleoside phosphoramidite intermediates, and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared through the protection of one or more internucleosidic phosphorus functionalities, preferably followed by oxidation and cleavage of the protecting groups to provide oligonucleotides. Methods for preparing oligoribonucleotides are also disclosed.

  本发明揭示了Novel P(III)双酰胺试剂作为磷保护基，核苷酸磷酰胺中间体和制备它们的合成过程。此外，通过保护一个或多个核苷酸之间的磷功能基，最好是随后进行氧化和去保护基，以提供寡核苷酸，制备寡聚化合物。本发明还揭示了制备寡核糖核酸的方法。
• Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
  申请人：Takara Bio USA, Inc.

  公开号：US10584363B2

  公开（公告）日：2020-03-10

  Methods of producing single-stranded deoxyribonucleic acids (ssDNAs) are provided. Aspects of the methods include generating a double stranded deoxyribonucleic acid (dsDNA) and then selectively degrading one strand of the dsDNA to produce a ssDNA. ssDNAs produced using methods of the invention find use in a variety of applications, including genomic modification applications. Also provided are compositions, e.g., kits, that find use in practicing various embodiments of the invention.

  本文提供了生产单链脱氧核糖核酸（ssDNA）的方法。 这些方法的各个方面包括产生双链脱氧核糖核酸（dsDNA），然后选择性地降解dsDNA的一条链以产生ssDNA。使用本发明方法产生的ssDNA可用于各种应用，包括基因组修饰应用。 此外，还提供了可用于实施本发明各种实施方案的组合物，如试剂盒。
• Methods for detecting agglutination and compositions for use in practicing the same
  申请人：The Regents of the University of California

  公开号：US11149296B2

  公开（公告）日：2021-10-19

  Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the antigen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided.

  提供了检测样品中抗原结合剂的方法。这些方法的各个方面包括通过与抗原结合的多核苷酸的灵敏近距离结合来检测抗原结合剂与多核苷酸结合抗原的聚集。这些方法的各个方面还包括通过核酸扩增来检测这种基于近距离结合的方法。此外，还提供了有助于实施本方法各实施例的组合物，如试剂、试剂盒和装置。
• Method for purifying 5'-protected 2'-deoxypurine nucleosides
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1253154B1

  公开（公告）日：2009-09-02