1-nonanoyl-hexahydro-azepine | 20308-66-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环庚烷
• 英文名称: 1-nonanoyl-hexahydro-azepine
• 英文别名: 1-Nonanoyl-hexahydro-azepin；1-(Azepan-1-yl)nonan-1-one
• CAS: 20308-66-1
• 化学式: C₁₅H₂₉NO
• mdl: MFCD03381716
• 分子量: 239.401
• InChiKey: JXSJWHXALVHMGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.933
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环己亚胺 以84%的产率得到
  参考文献：
  名称：

  RAJAKHYAKSHA, VITHAL J.

  摘要：

  DOI：

文献信息

• Penetration enhancers for transdermal delivery of systemic agents
  申请人：Whitby Research Incorporated

  公开号：EP0268219A1

  公开（公告）日：1988-05-25

  This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula wherein X is selected from the group consisting of oxygen and sulfur; Rʹ is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; and n is 0-17.

  本发明涉及一种在透皮装置或制剂中通过人和动物的皮肤或粘膜施用全身活性剂（包括治疗剂）的方法，包括与所述全身性制剂一起局部施用有效量的膜渗透促进剂，其结构式为 其中 X 选自由氧和硫组成的组；Rʹ 是 H 或具有 1-4 个碳原子的低级烷基；m 是 2-6；n 是 0-17。
• RESIN COMPOSITION
  申请人：Zeon Corporation

  公开号：EP1903074A1

  公开（公告）日：2008-03-26

  A resin composition comprising alicyclic structure-containig polymer such as additional copolymer with monomer having norbornene structure and ethylene, hydrogenated product of ring-opening polymer with monomer having norbornene structure, and aromatic ring-hydrogenated product of copolymer with styrene and isoprene; and piperidine derivatives such as N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)-N,N'-diformyl-hexamethylenediamine and 4-(formyl amino)-2,2,6,6-tetramethyl piperidine.

  一种树脂组合物，包括含脂环结构的聚合物，如降冰片烯结构单体与乙烯的附加共聚物、降冰片烯结构单体开环聚合物的氢化产物、苯乙烯与异戊二烯共聚物的芳香环氢化产物；哌啶衍生物，如 N,N'-双（2,2,6,6-四甲基-4-哌啶基）-N,N'-二甲酰基六甲基二胺和 4-（甲酰氨基）-2,2,6,6-四甲基哌啶。
• Ibuprofen salt emulsifiers and cream formulations containing same
  申请人：Krauser F. Scott

  公开号：US20050032900A1

  公开（公告）日：2005-02-10

  Emulsions and creams containing ibuprofen effective for topical administration of the ibuprofen are provided without the presence of conventional O/W emulsifying agent. The emulsions and creams are formed by using the ibuprofen, in the form of its salt, as the O/W emulsifying agent. A minor amount of a W/O emulsifying agent may be included in the composition. Percutaneous delivery of ibuprofen is improved by using a skin penetration enhancing compound, such as 2-n-nonyl-1,3-dioxolane or decanaldimethyl acetal, as the oily phase of the emulsion.

  含有布洛芬的乳液和膏霜可有效用于布洛芬的局部用药，而无需使用传统的水包油型乳化剂。这些乳液和膏霜是以布洛芬盐的形式作为水包油型乳化剂形成的。组合物中可加入少量的水包油型乳化剂。使用皮肤渗透增强化合物，如 2-壬基-1,3-二氧戊环或癸醛二甲基缩醛，作为乳液的油相，可改善布洛芬的经皮给药。
• Pungents. Fatty Acid Amides¹
  作者：Leonard M. Rice、Charles H. Grogan、Bernard H. Armbrecht、E. Emmet Reid

  DOI：10.1021/ja01643a043

  日期：1954.7
• RAJAKHYAKSHA, VITHAL J.
  作者：RAJAKHYAKSHA, VITHAL J.

  DOI：——

  日期：——