6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexanoic acid | 127130-56-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexanoic acid
• 英文别名: 6-[Bis(4-methoxyphenyl)-phenylmethoxy]hexanoic acid
• CAS: 127130-56-7
• 化学式: C₂₇H₃₀O₅
• 分子量: 434.532
• InChiKey: YWJXNLIDAXKMKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexanoic acid 、 {4-[3-(tert-Butyl-dimethyl-silanyloxy)-propoxy]-5-methoxy-2-nitro-phenyl}-methanol 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexanoic acid 4-[3-(tert-butyl-dimethyl-silanyloxy)-propoxy]-5-methoxy-2-nitro-benzyl ester
  参考文献：
  名称：

  Synthesis of Oligonucleotides Containing 3'-Alkyl Carboxylic Acids Using Universal, Photolabile Solid Phase Synthesis Supports

  摘要：

  The synthesis and application of photolabile supports for solid phase oligonucleotide syntheses that release oligonucleotides containing S'-alkyl carboxylic acids is described. The carboxylic acid functionality is revealed without removing any other protecting groups throughout the biopolymer, and the protected oligonucleotides are amenable to reverse phase HPLC. The solid phase synthesis supports do not contain a nucleoside, making it possible to use a single support for the synthesis of oligonucleotides independent of their sequence. Individual solid phase synthesis supports differ according to the length of the alkyl tether between the 4,4'-dimethoxytrityl group which serves as the initiation site for oligonucleotide synthesis and the latent carboxylic acid. Eicosameric oligonucleotides are obtained in as high as 92% yield, under photolysis conditions that an known to produce less than 1% thymidine thymidine photodimers.

  DOI：

  10.1021/jo00116a019
• 作为产物：
  描述：

  6-羟基己酸乙酯 在 水 、 三乙胺 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 6-(bis(4-methoxyphenyl)(phenyl)methoxy)hexanoic acid
  参考文献：
  名称：

  寡核苷酸功能化的光笼策略及其在寡核苷酸标记和环化中的应用

  摘要：

  我们已经使用光笼策略来开发新型亚磷酰胺，并扩大通过固相合成修饰寡核苷酸的保护基。我们合成了5个光不稳定的亚磷酰胺和4个新的光不稳定控制的孔玻璃（CPG）。通过使用这些对光不稳定的亚磷酰胺和CPG，可以轻松合成在5'和/或3'末端带有磷酸盐，胺，酸，硫醇和羰基的修饰的寡脱氧核苷酸（ODN）。据我们所知，这是第一个报道，在ODN的5'端引入一个羰基，在光不稳定的改性剂的两个末端引入硫醇基。末端标记也可以通过溶液或柱上固相合成轻松实现。通过使用光不稳定胺改性剂和光不稳定酸CPG，寡脱氧核苷酸的环化以良好的产率实现。这项研究提供了将功能基团引入寡核苷酸并扩大寡核苷酸生物正交标记范围的另一种方法。

  DOI：

  10.1002/chem.201103833

文献信息

• MODIFIED DOUBLE-STRANDED POLYNUCLEOTIDE
  申请人：Koizumi Makoto

  公开号：US20120220649A1

  公开（公告）日：2012-08-30

  The present invention provides a double-stranded polynucleotide having a sense strand polynucleotide consisting of a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, wherein an aryl or heteroaryl compound is bound to a phosphate group at the 5′-end of the antisense strand polynucleotide.

  本发明提供了一种双链聚核苷酸，其具有一个具有与目标基因中的目标序列互补的核苷酸序列的正链聚核苷酸，以及一个具有与正链聚核苷酸互补的核苷酸序列的反义链聚核苷酸，其中一种芳基或杂环芳基化合物结合到反义链聚核苷酸的5'-末端的磷酸基团上。
• Modified Single-Stranded Polynucleotide
  申请人：Koizumi Makoto

  公开号：US20130253038A1

  公开（公告）日：2013-09-26

  It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5′-end of the antisense strand and the 3′-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.

  本发明旨在提供一种对RNase具有抗性并具有RNA干扰效应的多核苷酸。本发明提供了一种单链多核苷酸，其源自于包含与目标基因相对应的正义链多核苷酸和具有与正义链多核苷酸互补的核苷酸序列的反义链多核苷酸的双链多核苷酸，且具有一种结构，其中反义链的5'-末端和正义链的3'-末端通过含苯基的连接剂连接形成磷酸二酯结构。
• MODIFIED SINGLE-STRAND POLYNUCLEOTIDE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2647713A1

  公开（公告）日：2013-10-09

  It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5'-end of the antisense strand and the 3'-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.

  本发明旨在提供一种能抗 RNase 并具有 RNA 干扰作用的多核苷酸等。本发明提供了一种由双链多核苷酸衍生的单链多核苷酸，双链多核苷酸包括与靶基因相对应的有义链多核苷酸和具有与有义链多核苷酸互补的核苷酸序列的反义链多核苷酸、其结构是反义链的 5'-端和有义链的 3'-端通过含苯基的连接体连接，在这两端分别形成磷酸二酯结构。
• UNIFORM SEQUENCE-DEFINED POLYURETHANES AND USES THEREOF AS MOLECULAR LABELS
  申请人：Centre National de la Recherche Scientifique CNRS

  公开号：EP3243857A1

  公开（公告）日：2017-11-15

  The present disclosure relates to sequence-defined polyurethanes and methods of making and using same.

  本公开涉及序列确定的聚氨酯及其制造和使用方法。
• Uniform sequence-defined polyurethanes and uses thereof as molecular labels
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US11359054B2

  公开（公告）日：2022-06-14

  Some embodiments are directed to sequence-defined polyurethanes and methods of making and using same.

  某些实施方案涉及序列定义聚氨酯及其制造和使用方法。