2-[(2-Chlorophenyl)-diphenylmethoxy]ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-[(2-Chlorophenyl)-diphenylmethoxy]ethanol
• 化学式: C₂₁H₁₉ClO₂
• 分子量: 338.8
• InChiKey: QSTYUTDWLMHTOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
  申请人：Syngenta Limited

  公开号：US20030144263A1

  公开（公告）日：2003-07-31

  Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, 1 wherein, for example, X is —O— or —S—; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, Q1 and Q2 2 R 2 and R 3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5): 3 wherein Rc is, for example, R 13 CO—, R 13 SO 2 — or R 13 CS—; wherein R 13 is, for example, optionally substituted (1-10C)alkyl or R 14 C(O)O(1-6C)alkyl wherein R 14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

  式(I)的化合物，或其药学上可接受的盐，或其体内可水解的酯， 其中，例如，X为—O—或—S—； HET是一个可选择的取代的C-连接的含有2到4个异原子（独立选择自N、O和S）的5元杂芳环； Q从Q1和Q2中选择 R2和R3独立地为氢或氟； T从一系列基团中选择，例如，一个N-连接的（完全不饱和的）5元杂芳环系统或式(TC5)的基团： 其中Rc是，例如，R13CO—，R13SO2—或R13CS—； 其中R13是，例如，可选择的取代的(1-10C)烷基或R14C(O)O(1-6C)烷基 其中R14是可选择的取代的(1-10C)烷基；这些化合物可用作抗菌剂；并描述了其制备方法和含有它们的药物组合物。
• Oxazolidinone derivatives with antibiotic activity
  申请人：——

  公开号：US20030216373A1

  公开（公告）日：2003-11-20

  Compounds of the formula (I), or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, 1 wherein HET is an N-linked 5-membered heteroaryl ring, optionally substituted on a C atom by an oxo or thioxo group; and/or by 1 or 2 (1-4C)alkyl groups; and/or on an available nitrogen atom by (1-4C)alkyl; or HET is an N-linked 6-membered heteroaryl ring containing up to three nitrogen heteroatoms in total, optionally substituted on a C atom as above; Q is selected from, for example, Q1 2 R 2 and R 3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, of formula (TC 5 ) 3 wherein Rc is, for example, R 13 CO—, R 13 SO 2 — or R 13 CS—; wherein R 13 is, for example, optionally substituted (1-10C)alkyl or R 14 C(O)O(1-6C)alkyl wherein R 14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

  公式(I)的化合物，或其药学上可接受的盐，或其体内水解酯，其中HET是一个N-连接的5-成员杂环芳基环，可选地在碳原子上被氧化或硫代氧基取代；和/或由1或2个（1-4C）烷基基团取代；和/或在一个可用的氮原子上由（1-4C）烷基基团取代；或者HET是一个N-连接的6-成员杂环芳基环，总共包含最多三个氮杂原子，可选地在碳原子上如上所述取代；Q是选自，例如，Q12R2和R3独立地是氢或氟；T是选自一系列基团，例如，如下式（TC5）3其中Rc是，例如，R13CO—，R13SO2—或R13CS—；其中R13是，例如，可选地取代的（1-10C）烷基或R14C(O)O(1-6C)烷基，其中R14是可选地取代的（1-10C）烷基；作为抗菌剂是有用的；并描述了它们的制备方法和含有它们的药物组合物。
• [EN] OXAZOLIDINONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY<br/>[FR] DERIVES D'OXAZOLIDINONE AYANT UNE ACTIVITE ANTIBIOTIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2001081350A1

  公开（公告）日：2001-11-01

  Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein HET is an N-linked 5-membered heteroaryl ring, optionally substituted on a C atom by an oxo or thioxo group; and/or by 1 or 2(1-4C) alkyl groups; and/or on an available nitrogen atom by (1-4C)alkyl; or HET is an N-linked 6-membered heteroaryl ring containing up to three nitrogen heteroatoms in total, optionally substituted on a C atom as above; Q is selected from, for example, (Q1), R?2 and R3¿ are independently hydrogen or fluoro; T is selected from a range of groups, for example, of formula (TC5), wherein Rc is, for example, R?13CO-, R13SO¿2- or R13CS-; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

  公式（I）的化合物，或其药学上可接受的盐，或其体内可水解的酯，其中HET是N-连接的5成员杂芳环，可选择在C原子上由氧或硫代氧基取代; 和/或由1或2（1-4C）烷基取代; 和/或在可用的氮原子上由（1-4C）烷基取代; 或者HET是N-连接的6成员杂芳环，总共包含最多三个氮杂原子，可选择在C原子上如上所述取代; Q是从（Q1）中选择，R？2和R3¿独立地为氢或氟; T是从一系列基团中选择，例如公式（TC5），其中Rc是例如R？13CO-，R13SO¿2-或R13CS-;其中R13例如是可选择取代的（1-10C）烷基或R14C（O）O（1-6C）烷基，其中R14是可选择取代的（1-10C）烷基; 适用于抗菌剂; 并描述了其制造过程和含有它们的制药组合物。
• OXAZOLIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：AstraZeneca UK Limited

  公开号：EP1082323A2

  公开（公告）日：2001-03-14
• OXAZOLIDINONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1286998B1

  公开（公告）日：2004-06-09