1-[5-(Azidomethyl)-4-hydroxyoxolan-2-yl]-5-fluoropyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 2 '，5'-二脱氧核苷
• 英文名称: 1-[5-(Azidomethyl)-4-hydroxyoxolan-2-yl]-5-fluoropyrimidine-2,4-dione
• 英文别名: 1-[5-(azidomethyl)-4-hydroxyoxolan-2-yl]-5-fluoropyrimidine-2,4-dione
• 化学式: C9H10FN5O4
• 分子量: 271.21
• InChiKey: GAWTWVNSTCYFSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] 2',5'-DIDEOXY-5-FLUOROURIDINE DERIVATIVES HAVING CYTOTOXIC ACTIVITY, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF<br/>[FR] DÉRIVÉS DE 2',5'-DIDÉSOXY-5-FLUOROURIDINE PRÉSENTANT UNE ACTIVITÉ CYTOTOXIQUE, LEUR PROCÉDÉ DE FABRICATION ET LEUR APPLICATION
  申请人：UNIV ADAM MICKIEWICZ

  公开号：WO2015041550A1

  公开（公告）日：2015-03-26

  The subject matter of the invention is novel 2',5'-dideoxy-5-fluorouridine derivatives of general formula 1. (1) wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8and C-9 atoms. In a second aspect, the subject matter of the invention is a process for the manufacture of 2',5'- dideoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2',5'-dideoxy-5- fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.

  本发明的主题是一种新型的通式1的2',5'-二去氧-5-氟尿苷衍生物。(1)其中R1表示奎宁生物碱片段，在C-8和C-9原子处具有定义的绝对构型。在第二方面，本发明的主题是一种制造通式1的2',5'-二去氧-5-氟尿苷衍生物的方法。在第三方面，本发明的主题是将通式1的2',5'-二去氧-5-氟尿苷衍生物应用于乳腺癌、宫颈癌、肺癌和鼻咽癌的抗癌治疗中。
• 2', 5' -DIDEOXY-5-FLUOROURIDINE DERIVATIVES HAVING CYTOTOXIC ACTIVITY, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF
  申请人：ADAM MICKIEWICZ UNIVERSITY

  公开号：US20160244473A1

  公开（公告）日：2016-08-25

  The subject matter of the invention is novel 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1. wherein R 1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. In a second aspect, the subject matter of the invention is a process for the manufacture of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2′,5′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
• US9605017B2
  申请人：——

  公开号：US9605017B2

  公开（公告）日：2017-03-28