N-[3-(tritylamino)-2,2-dimethylpropyl]benzamide | 1446714-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-[3-(tritylamino)-2,2-dimethylpropyl]benzamide
• 英文别名: N-[2,2-dimethyl-3-(tritylamino)propyl]benzamide
• CAS: 1446714-13-1
• 化学式: C₃₁H₃₂N₂O
• 分子量: 448.608
• InChiKey: LCIFODLZZOOWLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二甲基丙二胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 生成 N-[3-(tritylamino)-2,2-dimethylpropyl]benzamide
  参考文献：
  名称：

  Cyclodehydration of N-(Aminoalkyl)benzamides under Mild Conditions with a Hendrickson Reagent Analogue

  摘要：

  Methods for the cydodehydration of N-(aminoalkyl)benzamides are few and employ harsh reaction conditions. We have found that the easily prepared phosphonium anhydrides 1 (Hendrickson reagent) or 2 can be used for cyclodehydration of N-(aminoalkyl)benzamides under very mild conditions (room temperature) to produce five-, six-, and seven-membered cyclic amidines. Good yields are obtained by employing a temporary trityl group protection strategy. Cyclic analogue 2 can be used when the product cyclic amidine is organic-soluble, thus producing water-soluble byproducts.

  DOI：

  10.1021/jo401082q

文献信息

• Cyclodehydration of <i>N</i>-(Aminoalkyl)benzamides under Mild Conditions with a Hendrickson Reagent Analogue
  作者：Wendy A. Loughlin、Ian D. Jenkins、Maria J. Petersson

  DOI：10.1021/jo401082q

  日期：2013.7.19

  Methods for the cydodehydration of N-(aminoalkyl)benzamides are few and employ harsh reaction conditions. We have found that the easily prepared phosphonium anhydrides 1 (Hendrickson reagent) or 2 can be used for cyclodehydration of N-(aminoalkyl)benzamides under very mild conditions (room temperature) to produce five-, six-, and seven-membered cyclic amidines. Good yields are obtained by employing a temporary trityl group protection strategy. Cyclic analogue 2 can be used when the product cyclic amidine is organic-soluble, thus producing water-soluble byproducts.