8-bromo-1-(4-dimethylaminophenyl)-1,2,3,4-tetrahydrodipyrido[1,2-a;4',3'-d]imidazole | 1403658-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并[1，2-a]吡啶
• 英文名称: 8-bromo-1-(4-dimethylaminophenyl)-1,2,3,4-tetrahydrodipyrido[1,2-a;4',3'-d]imidazole
• 英文别名: 4-(12-bromo-1,4,8-triazatricyclo[7.4.0.02,7]trideca-2(7),8,10,12-tetraen-3-yl)-N,N-dimethylaniline
• CAS: 1403658-82-1
• 化学式: C₁₈H₁₉BrN₄
• 分子量: 371.28
• InChiKey: QDRVBESAWSKUNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[2-(6-bromoimidazo[1,2-a]pyridin-2-yl)ethyl]-1Hisoindole-1,3(2H)-dione 在 一水合肼 、 三氟乙酸 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 28.0h， 生成 8-bromo-1-(4-dimethylaminophenyl)-1,2,3,4-tetrahydrodipyrido[1,2-a;4',3'-d]imidazole
  参考文献：
  名称：

  Methodology to Access Tetrahydrodipyridoimidazole Derivatives

  摘要：

  While the synthesis of beta and gamma-carboline derivatives were well described in the literature, the preparation of their aza-analogs such as tetrahydrodipyridoimidazole derivatives were less explored. In our laboratory we developed various methods to access to these compounds using Bischler-Napieralski as well as Pictet-Spengler reactions.

  DOI：

  10.3987/com-12-12447

文献信息

• Methodology to Access Tetrahydrodipyridoimidazole Derivatives
  作者：Pascal Carato、Mohamed El Bousmaqui、Marion Donnier-Marechal、Paul-Emmanuel Larchanche、Patricia Melnyk

  DOI：10.3987/com-12-12447

  日期：——

  While the synthesis of beta and gamma-carboline derivatives were well described in the literature, the preparation of their aza-analogs such as tetrahydrodipyridoimidazole derivatives were less explored. In our laboratory we developed various methods to access to these compounds using Bischler-Napieralski as well as Pictet-Spengler reactions.