6-ethyl-N-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-amine | 423736-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 6-ethyl-N-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-amine
• CAS: 423736-67-8
• 化学式: C₁₅H₁₅N₃S
• 分子量: 269.37
• InChiKey: YGGUOCXZLNZBPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯-6-乙基噻吩并[2,3-d]嘧啶 、 乙烷,三氯氟- 以 异丙醇 为溶剂， 反应 0.43h， 以98%的产率得到6-ethyl-N-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  Microwave-based synthesis of novel thienopyrimidine bioisosteres of gefitinib

  摘要：

  A series of novel 2-unsubstituted 4-(substituted)anilinothieno[2,3-d]pyrimidines is synthesized through the chlorination of the corresponding 2-unsubstituted-thieno[2,3-d]-pyrimidin-4-ones, followed by the nucleophilic displacement of the 4-Cl group of 9, with a variety of anilines. All four steps of this synthesis involve microwave irradiation (MWI) and the entire synthesis requires only 2 h. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.135

文献信息

• Microwave-based synthesis of novel thienopyrimidine bioisosteres of gefitinib
  作者：Manisha S. Phoujdar、Muthu K. Kathiravan、Jitender B. Bariwal、Anamik K. Shah、Kishor S. Jain

  DOI：10.1016/j.tetlet.2007.11.135

  日期：2008.2

  A series of novel 2-unsubstituted 4-(substituted)anilinothieno[2,3-d]pyrimidines is synthesized through the chlorination of the corresponding 2-unsubstituted-thieno[2,3-d]-pyrimidin-4-ones, followed by the nucleophilic displacement of the 4-Cl group of 9, with a variety of anilines. All four steps of this synthesis involve microwave irradiation (MWI) and the entire synthesis requires only 2 h. (c) 2007 Elsevier Ltd. All rights reserved.