2-Methyl-4,6-diamino-thiazolo<5,4-d>pyrimidin | 89712-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 1,3-噻唑并[5,4-d]嘧啶
• 英文名称: 2-Methyl-4,6-diamino-thiazolo<5,4-d>pyrimidin
• 英文别名: 2-methyl-thiazolo[5,4-d]pyrimidine-5,7-diamine；2-methyl-thiazolo[5,4-d]pyrimidine-5,7-diyldiamine；2-Methyl-thiazolo[5,4-d]pyrimidin-5,7-diyldiamin；2-Methyl-[1,3]thiazolo[5,4-d]pyrimidine-5,7-diamine；2-methyl-[1,3]thiazolo[5,4-d]pyrimidine-5,7-diamine
• CAS: 89712-91-4
• 化学式: C₆H₇N₅S
• 分子量: 181.221
• InChiKey: UIVCWPPLMUDDQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5,7-二氯-2-甲基-噻唑并[5,4-d]嘧啶 在 ammonium hydroxide 作用下， 生成 2-Methyl-4,6-diamino-thiazolo<5,4-d>pyrimidin
  参考文献：
  名称：

  Thiazolopyrimidines

  摘要：

  DOI：

  10.1021/ja01152a090

文献信息

• The Direct Thiation of Pyrimidinol Derivatives.
  作者：Takeo Ueda、Tadakazu Tsuji、Hiroko Momona

  DOI：10.1248/cpb.11.912

  日期：——

  The replacement of 4-hydroxyl group of aminopyrimidinols by sulfhydryl in one step, through the action of phosphorus pentasulfide in triethylamine or 3-picoline. 5-Acylamino-6-amino-4-pyrimidinols were treated with phosphorus pentasulfide in pyridine, to yield thiazolo [5, 4-d] pyrimidine and 6-purinethiol compounds. The yield of both two type compounds were changed according to a functional group in the starting substance. These products, in addition, other 6-purinethiol and related compounds were screened as to their antiviral activities on poliomyelitis virus. Any of the compounds, however, did not exert a significant activity on the virus.

  通过三乙胺或3-吡啶的作用，采用五硫化磷在一步中替换氨基嘧啶醇的4-羟基为巯基。5-酰氨基-6-氨基-4-嘧啶醇在吡啶中与五硫化磷反应，得到噻唑并[5, 4-d]嘧啶和6-嘌呤巯基化合物。两种类型化合物的产率根据起始物质中的功能团有所变化。此外，这些产品以及其他6-嘌呤巯基及相关化合物被筛选以评估其对脊髓灰质炎病毒的抗病毒活性。然而，任何化合物都没有对病毒展现出显著的活性。
• Studies on Condensed Pyrimidine Systems. IV.¹ Some Thiazolo [5,4-d] pyrimidines
  作者：Elvira A. Falco、George H. Hitchings

  DOI：10.1021/ja01163a112

  日期：1950.7