7-Methyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione | 1026177-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 7-Methyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione
• CAS: 1026177-14-9
• 化学式: C₇H₈N₂O₂S
• 分子量: 184.219
• InChiKey: GGNNODHPIYFMNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 7-Methyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione 在 sodium hydroxide 作用下， 反应 24.0h， 以90%的产率得到5-Benzylsulfanyl-6-isopropenyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Unusual Ring-Opening Reaction of 6,7-Dihydrothieno[3,2-d]pyrimidine-2,4-dione Derivatives Leading to 5-(Alkylthio)-6-vinyluracils

  摘要：

  DOI：

  10.1021/jo00110a057
• 作为产物：
  描述：

  N-<2-(Methoxycarbonyl)-4-methyl-4,5-dihydrothiophen-3-yl>urea 在 sodium hydroxide 作用下， 反应 0.5h， 以68%的产率得到7-Methyl-6,7-dihydro-1H-thieno[3,2-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  Unusual Ring-Opening Reaction of 6,7-Dihydrothieno[3,2-d]pyrimidine-2,4-dione Derivatives Leading to 5-(Alkylthio)-6-vinyluracils

  摘要：

  DOI：

  10.1021/jo00110a057

文献信息

• Aromatic Compound
  申请人：Furukubo Shigeru

  公开号：US20090182142A1

  公开（公告）日：2009-07-16

  An aromatic compound represented by the following formula or a pharmaceutically acceptable salt thereof: , wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., G 1 , G 2 , G 3 , G 4 and G 5 are CH or N, X is —NH—, —O—, —CH 2 —, etc., Y is —CH 2 —, —CO—, —SO 2 —, etc., Z is a single bond, —CO—, —SO 2 —, —NH—, —O—, —S—, —CONH—, —SO 2 NH—, etc., R 2 is hydrogen, alkyl, alkoxy, halogen, etc., and R 3 is carbocyclic group, heterocyclic group, alkyl, etc., is useful as a controlling agent of the function of CCR4 useful for the treatment or therapy for bronchial asthma, atopic dermatitis, etc.

  下列的芳香族化合物或其药学上可接受的盐，其化学式如下：其中环A为杂环，环B为碳环、杂环等，G1、G2、G3、G4和G5为CH或N，X为—NH—、—O—、—CH2—等，Y为—CH2—、—CO—、—SO2—等，Z为单键、—CO—、—SO2—、—NH—、—O—、—S—、—CONH—、—SO2NH—等，R2为氢、烷基、烷氧基、卤素等，而R3为碳环基、杂环基、烷基等。该化合物对于控制CCR4功能的作用剂对于治疗或治疗支气管哮喘、特应性皮炎等疾病是有用的。
• [EN] SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS<br/>[FR] SYNTHÈSE DE DIOLS DIHYDROTHIÉNO[3,2-d]PYRIMIDINIQUES ET DE DIOLS PYRIMIDINIQUES ANALOGUES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009140127A3

  公开（公告）日：2010-01-28
• SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2315755A2

  公开（公告）日：2011-05-04
• SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS
  申请人：Frutos Rogelio Perez

  公开号：US20110130563A1

  公开（公告）日：2011-06-02

  The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
• US8471010B2
  申请人：——

  公开号：US8471010B2

  公开（公告）日：2013-06-25