2-[4-(dimethylamino)phenyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one | 357619-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 2-[4-(dimethylamino)phenyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
• 英文别名: 2-[4-(dimethylamino)phenyl]-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-4-one
• CAS: 357619-21-7
• 化学式: C₁₈H₁₉N₃OS
• mdl: MFCD00773595
• 分子量: 325.434
• InChiKey: GIYJBJPJHYBXTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[4-(dimethylamino)phenyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one 在 三氯氧磷 作用下， 反应 6.0h， 生成
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study

  摘要：

  DOI：

  10.1080/14756366.2021.2010729
• 作为产物：
  描述：

  环己酮 在 sulfur 作用下， 以 乙醇 为溶剂， 反应 12.0h， 生成 2-[4-(dimethylamino)phenyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
  参考文献：
  名称：

  ZnO-CeO2纳米复合材料：制备噻吩并[2,3-d]嘧啶-4(3H)-one衍生物的高效催化剂

  摘要：

  摘要 采用共沉淀法制备氧化锌-氧化铈(ZnO-CeO2)纳米复合材料，并通过X射线衍射(XRD)、场发射扫描电子显微镜(FE-SEM)和粒度分布分析对其进行表征。XRD图显示氧化铈的立方相作为主要相。FE-SEM 图像显示了样品中氧化锌和氧化铈的均匀性分布。通过动态光散射技术测定的纳米复合材料的平均粒径为 58 nm。ZnO-CeO2 纳米复合材料的催化活性在噻吩并[2,3-d]嘧啶-4(3H)-one 衍生物的合成中进行了检测。在所有情况下，产品都以良好到极好的收率获得。

  DOI：

  10.1515/mgmc-2017-0038

文献信息

• ZnO-CeO2 nanocomposite: efficient catalyst for the preparation of thieno[2,3-d]pyrimidin-4(3H)-one derivatives
  作者：Farzaneh Ghayour、Mohammad Reza Mohammad Shafiee、Majid Ghashang

  DOI：10.1515/mgmc-2017-0038

  日期：2018.4.13

  mean particle size of the nanocomposite determined by dynamic light scattering technique was 58 nm. The catalytic activity of ZnO-CeO2 nanocomposite was examined on the synthesis of thieno[2,3-d]pyrimidin-4(3H)-one derivatives. In all cases, the products were obtained in good to excellent yields.

  摘要 采用共沉淀法制备氧化锌-氧化铈(ZnO-CeO2)纳米复合材料，并通过X射线衍射(XRD)、场发射扫描电子显微镜(FE-SEM)和粒度分布分析对其进行表征。XRD图显示氧化铈的立方相作为主要相。FE-SEM 图像显示了样品中氧化锌和氧化铈的均匀性分布。通过动态光散射技术测定的纳米复合材料的平均粒径为 58 nm。ZnO-CeO2 纳米复合材料的催化活性在噻吩并[2,3-d]嘧啶-4(3H)-one 衍生物的合成中进行了检测。在所有情况下，产品都以良好到极好的收率获得。
• Three possible products from the reactions of gewald's amide with aromatic aldehydes
  作者：Sergey G. Dzhavakhishvili、Nikolay Yu. Gorobets、Vladimir I. Musatov、Sergey M. Desenko、Boris V. Paponov

  DOI：10.1002/jhet.5570450243

  日期：2008.3

  Transformations of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (Gewald's amide) in the reactions with aromatic aldehydes were studied. Efficient methods for synthesis of three possible types of products: 2-aryl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, 2-(1-arylmethylidene-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide and 2-aryl-2,3,5,6,7,8-hexahydro[1]benzo-thieno[2

  研究了2-氨基-4,5,6,7-四氢苯并[ b ]噻吩-3-羧酰胺（Gewald's amide）在与芳族醛的反应中的转化。合成三种可能类型产物的有效方法：2-芳基-5,6,7,8-四氢[1]苯并噻吩并[2,3 - d ]嘧啶-4（3 H）-one，2-（1-芳基亚甲基-氨基）-4,5,6,7-四氢苯并[ b ]噻吩-3-羧酰胺和2-芳基-2,3,5,6,7,8-六氢[1]苯并噻吩并[2,3 - d ]嘧啶-4（1 ħ） -酮衍生物被开发出来。通过过滤可以容易地分离所有产物，具有非常好的总产率。还研究了这些化合物的相互转化。
• NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE
  申请人：Smith W. Jeffrey

  公开号：US20070203236A1

  公开（公告）日：2007-08-30

  The present invention provides for compounds of formula (I)-(XIII), as well as pharmaceutically acceptable salts thereof, metabolites thereof, pro-drugs thereof, and pharmaceutical kits that include such compounds. The present invention also provides for the compounds of formula (I)-(XIII) for use in medical therapy or diagnosis. The present invention also provides for the use of the compounds of formula (I)-(XIII) in treating cancer in mammals (e.g., humans), as well inhibiting tumor cell growth in such mammals. The present invention also provides for methods of inhibiting FAS. The methods include contacting FAS with an effective amount of a compound of formula (I)-(XIII). The present invention also provides for methods of inhibiting the TE domain of the FAS. The methods include contacting the thioesterase TE domain of the FAS with an effective amount of a compound of formula (I)-(XIII). The present invention also provides for methods of treating cancer in mammals, as well as methods of inhibiting tumor cell growth in such mammals. The methods include administering a compound of formula (I)-(XIII) to a mammal in need of such treatment.
• Design, synthesis, and biological evaluation of new thieno[2,3-<i>d</i>] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study
  作者：Fatma M. Elmenier、Deena S. Lasheen、Khaled A. M. Abouzid

  DOI：10.1080/14756366.2021.2010729

  日期：2022.12.31