1,2-Cyclohexylidenglucose-3,5,6-phosphit | 32580-07-7

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: 1,2-Cyclohexylidenglucose-3,5,6-phosphit
• 英文别名: 3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-.alpha-D-glucofuranoside；O¹,O²-cyclohexane-1,1-diyl-O³,O⁵,O⁶-phosphanetriyl-α-D-glucofuranose；(2R,4R,8R,9S)-spiro[3,5,7,10,12,14-hexaoxa-11-phosphatetracyclo[9.2.1.02,9.04,8]tetradecane-6,1'-cyclohexane]
• CAS: 32580-07-7
• 化学式: C₁₂H₁₇O₆P
• 分子量: 288.237
• InChiKey: GATILVOOCMSDPQ-SEJBVYMDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,2-Cyclohexylidenglucose-3,5,6-phosphit 、 [RuII(η6-p-cymene)(PPh3)(CH3CN)Cl]PF6 以 二氯甲烷 为溶剂， 以96%的产率得到chlorido(3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-.alpha-D-glucofuranoside)(η6-p-cymene)(triphenylphosphine)ruthenium(II)hexafluorophosphate
  参考文献：
  名称：

  Synthesis of [RuII(η6-p-cymene)(PPh3)(L)Cl]PF6 complexes with carbohydrate-derived phosphites, imidazole or indazole co-ligands

  摘要：

  Ru-II(arene) complexes of the general formula [Ru-II(eta(6)-p-cymene)(PPh3)(L)Cl]PF6 with L = P- or N-donor systems have been synthesized and characterized. Carbohydrate-derived phosphites, imidazole or indazole have been chosen as co-ligands and different synthetic routes have been explored to obtain the compounds. The organometallics were characterized by elemental analysis, electrospray ionization mass spectroscopy, H-1, C-13{H-1}, P-31{H-1} and 2D NMR spectroscopic methods. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.10.007

文献信息

• Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules
  作者：Muhammad Hanif、Alexey A. Nazarov、Anton Legin、Michael Groessl、Vladimir B. Arion、Michael A. Jakupec、Yury O. Tsybin、Paul J. Dyson、Bernhard K. Keppler、Christian G. Hartinger

  DOI：10.1039/c1cc14713g

  日期：——

  RuII(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

  制备了具有马来酰亚胺功能的 RuII（芴）抗癌化合物，使其能够与含硫醇的生物大分子发生选择性相互作用，从而使化合物能够选择性地输送到肿瘤中。
• Synthesis of [RuII(η6-p-cymene)(PPh3)(L)Cl]PF6 complexes with carbohydrate-derived phosphites, imidazole or indazole co-ligands
  作者：Muhammad Hanif、Alexey A. Nazarov、Christian G. Hartinger

  DOI：10.1016/j.ica.2011.10.007

  日期：2012.1

  Ru-II(arene) complexes of the general formula [Ru-II(eta(6)-p-cymene)(PPh3)(L)Cl]PF6 with L = P- or N-donor systems have been synthesized and characterized. Carbohydrate-derived phosphites, imidazole or indazole have been chosen as co-ligands and different synthetic routes have been explored to obtain the compounds. The organometallics were characterized by elemental analysis, electrospray ionization mass spectroscopy, H-1, C-13H-1}, P-31H-1} and 2D NMR spectroscopic methods. (C) 2011 Elsevier B.V. All rights reserved.