1-[5-(4,4'-dimethoxytrityl)-2-(t-butyldimethylsilyl)-4-thio-beta-D-ribofuranosyl]uracil | 149359-05-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-[5-(4,4'-dimethoxytrityl)-2-(t-butyldimethylsilyl)-4-thio-beta-D-ribofuranosyl]uracil
• 英文别名: TBDMS(-2)[DMT(-5)]4-thio-Ribf(b)-uracil-1-yl；1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxythiolan-2-yl]pyrimidine-2,4-dione
• CAS: 149359-05-7
• 化学式: C₃₆H₄₄N₂O₇SSi
• 分子量: 676.906
• InChiKey: KUYSHWOHDFQCFN-WXQJYUTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.93
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  氯(二异丙基氨基)甲氧基膦 、 1-[5-(4,4'-dimethoxytrityl)-2-(t-butyldimethylsilyl)-4-thio-beta-D-ribofuranosyl]uracil 以 二氯甲烷 为溶剂， 生成 Diisopropyl-phosphoramidous acid (2R,3S,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-thiophen-3-yl ester methyl ester
  参考文献：
  名称：

  4'-Thio-β-D-oligoribonucleotides: Nuclease Resistance and Hydrogen Bonding Properties

  摘要：

  The syntheses and the study of nuclease resistance and hydrogen bonding of modified oligoribonucleotides, i.e. 4'-thio-beta-D-oligoribonucleotides (4'-S-RNA), are reported.

  DOI：

  10.1080/15257779508012526
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 、 1-[5-(4,4-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]uracil 在 吡啶 作用下， 生成 1-[5-(4,4'-dimethoxytrityl)-2-(t-butyldimethylsilyl)-4-thio-beta-D-ribofuranosyl]uracil
  参考文献：
  名称：

  4'-Thio-β-D-oligoribonucleotides: Nuclease Resistance and Hydrogen Bonding Properties

  摘要：

  The syntheses and the study of nuclease resistance and hydrogen bonding of modified oligoribonucleotides, i.e. 4'-thio-beta-D-oligoribonucleotides (4'-S-RNA), are reported.

  DOI：

  10.1080/15257779508012526

文献信息

• [EN] 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS<br/>[FR] 4'-THIONUCLEOSIDES ET COMPOSES D'OLIGOMERES
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2005027962A3

  公开（公告）日：2007-07-12
• 4'-Thio-β-D-oligoribonucleotides: Nuclease Resistance and Hydrogen Bonding Properties
  作者：C. Leydier、L. Bellon、J. -L. Barascut、J. -L. Imbach

  DOI：10.1080/15257779508012526

  日期：1995.5.1

  The syntheses and the study of nuclease resistance and hydrogen bonding of modified oligoribonucleotides, i.e. 4'-thio-beta-D-oligoribonucleotides (4'-S-RNA), are reported.