1-chloroethyl 3-(2-(6-bromopyridin-2-yl)-2-methylhydrazono)-8-azabicyclo[3.2.1]octane-8-carboxylate | 1260400-78-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 1-chloroethyl 3-(2-(6-bromopyridin-2-yl)-2-methylhydrazono)-8-azabicyclo[3.2.1]octane-8-carboxylate
• 英文别名: 1-chloroethyl 3-[(6-bromopyridin-2-yl)-methylhydrazinylidene]-8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS: 1260400-78-9
• 化学式: C₁₆H₂₀BrClN₄O₂
• 分子量: 415.717
• InChiKey: LWPPKKVSSXYELD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-chloroethyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate 、 2-bromo-6-(1-methylhydrazinyl)pyridine 在 对甲苯磺酸 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 以28%的产率得到1-chloroethyl 3-(2-(6-bromopyridin-2-yl)-2-methylhydrazono)-8-azabicyclo[3.2.1]octane-8-carboxylate
  参考文献：
  名称：

  AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

  摘要：

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神障碍。本发明还描述了制备这些化合物的方法。

  公开号：

  US20110003737A1

文献信息

• Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
  申请人：Guzzo Peter R.

  公开号：US08629158B2

  公开（公告）日：2014-01-14

  Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

  本发明揭示了新型的MCH-1受体拮抗剂。这些化合物可用于治疗各种疾病，包括肥胖症、焦虑症、抑郁症、非酒精性脂肪肝病和精神障碍。本发明还描述了制备这些化合物的方法。
• US8629158B2
  申请人：——

  公开号：US8629158B2

  公开（公告）日：2014-01-14
• [EN] AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF<br/>[FR] ANTAGONISTES DE MCH-1 D’AZABICYCLOALCANE-INDOLE ET D’AZABICYCLOALCANE-PYRROLO-PYRIDINE, PROCÉDÉS DE PRÉPARATION, ET UTILISATION DE CEUX-CI
  申请人：ALBANY MOLECULAR RES INC

  公开号：WO2011003007A1

  公开（公告）日：2011-01-06

  Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.
• AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
  申请人：GUZZO Peter R.

  公开号：US20110003737A1

  公开（公告）日：2011-01-06

  Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神障碍。本发明还描述了制备这些化合物的方法。