4-formylphenyldihydrogenphosphate | 40299-46-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 4-formylphenyldihydrogenphosphate
• 英文别名: p-Formylphenylphosphat；phosphoric acid mono-(4-formylphenyl) ester；4-(formyl)phenyl phosphate；(4-Formylphenyl) dihydrogen phosphate
• CAS: 40299-46-5
• 化学式: C₇H₇O₅P
• 分子量: 202.103
• InChiKey: ISAZDYZOHLBJRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-甲酰基苯基磷酸二乙酯 在 三甲基溴硅烷 作用下， 以 乙腈 为溶剂， 反应 0.17h， 以3 g的产率得到4-formylphenyldihydrogenphosphate
  参考文献：
  名称：

  动态底物增强，用于鉴定针对一组蛋白质酪氨酸磷酸酶的特定的第二位结合片段

  摘要：

  研究第二个位点： 对磷酸甲酰苯酯被确定为蛋白质酪氨酸磷酸酶（PTP）的通用底物，并用于检查蛋白质的次级结合位点以特异性结合片段。通过在动态连接反应中扩增底物的周转来检测结合片段，并将其发展为高度特异性的PTP抑制剂。

  DOI：

  10.1002/cbic.201100414

文献信息

• PYRROLOTRIAZINE ANILINE PRODRUG COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：Liu Chunjian

  公开号：US20070213300A1

  公开（公告）日：2007-09-13

  Compounds having the Formula (I), including pharmaceutically acceptable salts thereof, wherein at least one of X 1 , X 2 or X 3 is and any remaining X 1 , X 2 or X 3 is hydrogen, which are useful as kinase inhibitors, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A 1 , A 2 and m are as described herein.

  具有化学式（I）的化合物，包括其药学上可接受的盐，其中X1、X2或X3中至少有一个是氢，其余的X1、X2或X3是氢，这些化合物可用作激酶抑制剂，其中R1、R2、R3、R4、R5、R6、A1、A2和m如本文所述。
• PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20190300526A1

  公开（公告）日：2019-10-03

  The present disclosure provides, inter alia, Compounds of Formulae IA, IB, IC, IIA, IIB and IIC or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.

  本公开提供了化合物IA、IB、IC、IIA、IIB和IIC的结构，或其在药学上可接受的盐，这些化合物是C5a受体的调节剂。还提供了包括治疗涉及C5a病理性激活的疾病或疾病的药物组合物和使用方法，以及非药物应用。
• NOVEL FURAZAN-3-CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN TREATMENT OF CANCER
  申请人：Freie Universität Berlin

  公开号：EP3305783A1

  公开（公告）日：2018-04-11

  A furazan-3-carboxylic acid derivative or pharmaceutically acceptable salt thereof for use in treatment of acute myeloid leukemia.

  用于治疗急性髓系白血病的呋嗪-3-羧酸衍生物或其药用盐。
• POLYVINYL ACETAL RESIN, SLURRY COMPOSITION PREPARED THEREFROM, CERAMIC GREEN SHEET, AND MULTILAYER CERAMIC CAPACITOR
  申请人：Kuraray Co., Ltd.

  公开号：EP2607390A1

  公开（公告）日：2013-06-26

  According to the present invention, provided is a polyvinyl acetal resin capable of obtaining a ceramic green sheet that has sufficient mechanical strength, in which the dimensional change in the storage of ceramic green sheet is small, and the delamination hardly occurs in the delipidation. The present invention relates to a polyvinyl acetal resin that has a degree of polymerization of 200 or more to 6000 or less, a content percentage of vinylester unit of 0.01 to 30 mol%, a degree of acetalization of 55 to 83 mol%, and a structural unit represented by Chemical formula (1): in a molecule.

  根据本发明，提供了一种聚乙烯醇缩醛树脂，它能够获得具有足够机械强度的陶瓷绿片，在陶瓷绿片的储存过程中尺寸变化小，在脱脂过程中几乎不发生分层。 本发明涉及一种聚乙烯醇缩醛树脂，其聚合度为 200 或以上至 6000 或以下，乙烯基酯单元含量百分比为 0.01 至 30 摩尔%，缩醛度为 55 至 83 摩尔%，结构单元由化学式（1）表示： 的结构单元。
• ALKYL-MODIFIED VINYL ACETAL POLYMER AND COMPOSITION
  申请人：Kuraray Co., Ltd.

  公开号：EP2692749A1

  公开（公告）日：2014-02-05

  Provided are a vinyl acetal polymer that has sufficient plasticity and solubility in an alcohol solvent, imparts low viscosity, stability, etc., to a solution thereof, is less likely to cause phase separation from other components, and allows for formation of a slurry superior in dispersibility of particles and thixotropic nature, as well as a sheet superior in strength and flexibility, and the like. An alkyl-modified vinyl acetal polymer obtained by subjecting an alkyl-modified vinyl alcohol polymer to acetalization, in which the alkyl-modified vinyl alcohol polymer comprises a monomer unit represented by the following general formula (I), and has a viscosity average degree of polymerization P of 150 or greater and 5,000 or less, a degree of saponification of 20 mol% or greater and 99.99 mol% or less, and a percentage of alkyl modification S with the monomer unit of 0.05 mol% or greater and 5 mol% or less.

  本发明提供了一种乙烯基缩醛聚合物，该聚合物在醇类溶剂中具有足够的可塑性和溶解性，可使其溶液具有低粘度和稳定性等，不易与其他成分发生相分离，并可形成在颗粒分散性和触变性方面更优越的浆料，以及在强度和柔韧性方面更优越的片材等。一种烷基改性乙烯基缩醛聚合物，通过对烷基改性乙烯基醇聚合物进行缩醛化而获得，其中烷基改性乙烯基醇聚合物包含由下式通式（I）表示的单体单元，其粘度平均聚合度 P 为 150 或以上、5000 或以下，皂化度为 20 摩尔％或以上、99.99 摩尔％或以下，烷基改性 S 与单体单元的百分比为 0.05 摩尔％或以上、5 摩尔％或以下。