9-Methyl-3-oxa-9-aza-spiro<5.5>undecane | 3301-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 9-Methyl-3-oxa-9-aza-spiro<5.5>undecane
• 英文别名: 9-methyl-3-oxa-9-aza-spiro[5.5]undecane；9-Methyl-3-oxa-9-azaspiro[5.5]undecane
• CAS: 3301-60-8
• 化学式: C₁₀H₁₉NO
• 分子量: 169.267
• InChiKey: QQCPTJJNECEXAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-Methyl-4,4-bis(2-hydroxy-aethyl)-piperidin 在 硫酸 作用下， 反应 3.0h， 生成 9-Methyl-3-oxa-9-aza-spiro<5.5>undecane
  参考文献：
  名称：

  Freed,M.E.; Rice,L.M., Journal of Heterocyclic Chemistry, 1965, vol. 2, p. 214 - 217

  摘要：

  DOI：

文献信息

• [EN] METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION<br/>[FR] MÉTHODES ET COMPOSÉS POUR LA RESTAURATION DE LA FONCTION DU P53 MUTANT
  申请人：PMV PHARMACEUTICALS INC

  公开号：WO2021061643A1

  公开（公告）日：2021-04-01

  Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

  癌基因和肿瘤抑制基因的突变促成了癌症的发展和进展。本公开披露描述了一种恢复p53突变体野生型功能的化合物和方法。本发明的化合物可以结合突变型p53，并恢复p53突变体结合DNA并激活参与肿瘤抑制的下游效应子的能力。所披露的化合物可用于减少含有p53突变的癌症的进展。
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US20140235634A1

  公开（公告）日：2014-08-21

  Described herein are compounds of Formula (I) or Formula (VI), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I) or Formula (VI) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating diseases are also provided.

  本文描述了公式（I）或公式（VI）的化合物，其药学上可接受的盐以及其药物组合物。还提供了包含公式（I）或公式（VI）化合物及其药物组合物的微粒（例如，纳米颗粒），这些微粒具有穿透黏液的特性。还提供了使用这些化合物或药物组合物治疗疾病的方法。
• PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS
  申请人：Incyte Corporation

  公开号：US20170190689A1

  公开（公告）日：2017-07-06

  The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

  本公开提供了化合物I的化合物，或其药用盐，其调节磷脂酰肌醇3-激酶-γ（PI3Kγ）的活性，并且在治疗与PI3Kγ活性相关的疾病方面具有用途，例如自身免疫疾病、癌症、心血管疾病和神经退行性疾病。
• [EN] 3-SUBSTITUTED CARBONYL-NAPHTHO[2,3-B]FURANE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF<br/>[FR] DÉRIVÉ DE CARBONYLE -NAPHTO [2,3-B]FURANE 3-SUBSTITUÉ DÉRIVÉ OU SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI
  申请人：BOSTON BIOMEDICAL INC

  公开号：WO2015120304A1

  公开（公告）日：2015-08-13

  The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: Formule (i) wherein X is an oxygen atom and the like; Y is -CO-, -S02-and the like; R1 is an optionally- substituted C1-6 alkyl group, an optionally-substituted C1-6 alkylcarbonyl group and the like; R2 is an optionally- substituted C1-6 alkyl group, an optionally-substituted C1-6 alkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R3, R4, R5, and R6 are independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

  本发明提供以下式（1）的化合物或其药学上可接受的盐：式（i）其中X是氧原子等；Y是-CO-，-S02-等；R1是可选择地取代的C1-6烷基，可选择地取代的C1-6烷基羰基等；R2是可选择地取代的C1-6烷基，可选择地取代的C1-6烷氧基，可选择地取代的氨基，可选择地取代的5-至12-成员的单环或多环饱和杂环基等；R3、R4、R5和R6独立地是氢原子等，对抑制癌细胞的增殖和球形形成能力具有出色效果，并可用作抗肿瘤药物或细胞生长抑制剂。
• CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT
  申请人：Nippon Soda Co., Ltd.

  公开号：US20200163336A1

  公开（公告）日：2020-05-28

  A pest control agent according to the present invention contains a compound of formula (I) (in the formula, Ar represents a substituted or unsubstituted C6-10 aryl group, R 1 represents a cyano group or a substituted or unsubstituted thiocarbamoyl group, R 2 represents a hydrogen atom, a halogeno group, a substituted or unsubstituted C1-6 alkyl group, a hydroxyl group, or a substituted or unsubstituted C1-6 alkoxy group, R 3 represents a hydrogen atom, a halogeno group, a substituted or unsubstituted C1-6 alkyl group, or the like, and Q represents a cyclic amino group) or a salt thereof.

  根据本发明，一种害虫控制剂包含化合物的公式（I）（在该式中，Ar代表取代或未取代的C6-10芳基，R1代表氰基或取代或未取代的硫代氨基基团，R2代表氢原子、卤素基团、取代或未取代的C1-6烷基基团、羟基或取代或未取代的C1-6烷氧基团，R3代表氢原子、卤素基团、取代或未取代的C1-6烷基基团等，Q代表环氨基基团）或其盐。