1-acetylbenzoisochromanquinone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异色满醌
• 英文名称: 1-acetylbenzoisochromanquinone
• 英文别名: (5,10-dioxo-3,4-dihydro-1H-benzo[g]isochromen-1-yl) acetate
• 化学式: C₁₅H₁₂O₅
• 分子量: 272.257
• InChiKey: AZLQFISEEGBZFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙酸酐 、 1-hydroxybenzoisochromanquinone 在 吡啶 作用下， 生成 1-acetylbenzoisochromanquinone
  参考文献：
  名称：

  Bio-active Compounds fromPsychotria camponutans

  摘要：

  A new benzoquinone (1-hydroxybenzoisochromanquinone) and benz[g]isoqumoline-5,10-dione have been isolated from the woody parts of Psychotria camponutans, as a result of bioactivity-guided fractionation. The compounds were characterized by UV, IR, EI-mass, 1H-, and 13C-NMR, and HETCOR NMR spectroscopy. Both compounds, together with acetylbenzoisochromanquinone, showed in vitro strong activity against brine shrimp, KB cells, and chloroquine-resistant P. falciparum.

  DOI：

  10.1055/s-2006-958001

文献信息

• Bio-active Compounds from<i>Psychotria camponutans</i>
  作者：Pablo Solis、Caroline Lang'at、Mahabir Gupta、Geoffrey Kirby、David Warhurst、J. Phillipson

  DOI：10.1055/s-2006-958001

  日期：1995.2

  A new benzoquinone (1-hydroxybenzoisochromanquinone) and benz[g]isoqumoline-5,10-dione have been isolated from the woody parts of Psychotria camponutans, as a result of bioactivity-guided fractionation. The compounds were characterized by UV, IR, EI-mass, 1H-, and 13C-NMR, and HETCOR NMR spectroscopy. Both compounds, together with acetylbenzoisochromanquinone, showed in vitro strong activity against brine shrimp, KB cells, and chloroquine-resistant P. falciparum.