AF150(S) | 138300-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: AF150(S)
• 英文别名: 2,8-dimethyl-1-thia-3,8-diaza-spiro[4.5]dec-2-ene；2,8-dimethyl-1-thia-3,8-diazaspiro[4.5]dec-2-ene
• CAS: 138300-72-8
• 化学式: C₉H₁₆N₂S
• 分子量: 184.305
• InChiKey: VGGGBQVTSUMURJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  AF150(S) 在 盐酸 、 溴甲酚绿 、 sodium cyanoborohydride 、 水 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 2,8-dimethyl-1-thia-3,8-diazaspiro[4.5]decane
  参考文献：
  名称：

  [EN] BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS
  [FR] COMPOSÉS SPIRO HÉTÉROCYCLIQUES BICYCLIQUES

  摘要：

  公开号：

  WO2010084499A9

文献信息

• Methods and pharmaceutical compositions for treatment of central and peripheral nervous system disorders and compounds useful therefor
  申请人：ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH

  公开号：US20040044018A1

  公开（公告）日：2004-03-04

  There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more Spiro compounds. Also provided and pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.

  提供了治疗涉及外周和中枢神经系统功能障碍的疾病的方法，包括给予一个或多个螺环化合物。还提供了在这些方法中有用的制药组合物，用于制备这些制药组合物的化合物，用于实践这些方法的有用化合物的制备过程，以及一些新的化合物本身。
• Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
  申请人：Fisher Abraham

  公开号：US20060052406A1

  公开（公告）日：2006-03-09

  There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.

  本发明提供了用于治疗涉及外周和中枢神经系统功能障碍的疾病的方法，包括给予一个或多个螺旋化合物。还提供了在这些方法中有用的制药组合物、用于制备这些制药组合物的化合物、制备这些方法中有用的化合物的过程，以及一些新的这样的化合物本身。
• Polyaminopyridines and method for producing same
  申请人：Kanbara Takaki

  公开号：US20060293503A1

  公开（公告）日：2006-12-28

  The present invention provides novel polyaminopyridines which are excellent in solubility in various solvents, and are preferably used in a polymer-type organic electroluminescent material, and a process for preparing the same. More particularly, the present invention provides polyaminopyridines having a repetition structural unit represented by the following general formula (1); and having a number average molecular weight in a range of 500 to 1000000.

  本发明提供了新型的聚氨基吡啶，其在各种溶剂中具有优异的溶解性，并且最好用于聚合物型有机电致发光材料，并提供了制备它们的过程。更具体地，本发明提供了具有以下一般式（1）所表示的重复结构单元的聚氨基吡啶，其具有500至1000000之间的数均分子量。
• METHODS AND COMPOSITIONS FOR TREATMENT OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISORDERS AND NOVEL COMPOUNDS USEFUL THEREFOR
  申请人：Fisher Abraham

  公开号：US20080306103A1

  公开（公告）日：2008-12-11

  There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more spiro compounds. Also provided are pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.

  提供了用于治疗涉及外周和中枢神经系统功能障碍的疾病的方法，包括给予一种或多种螺旋化合物。还提供了在这些方法中有用的制药组合物、用于制备这些制药组合物的化合物、用于实践这些方法的化合物的制备过程，以及一些新颖的化合物本身。
• BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS
  申请人：Fisher Abraham

  公开号：US20110281903A1

  公开（公告）日：2011-11-17

  There are disclosed bicyclic heterocyclic spiro compounds; pharmaceutical compositions comprising these compounds; and methods for the treatment in a mammal of diseases and conditions which are susceptible to modulation of the M1 muscarinic receptor, including Alzheimer's disease, insulin resistance syndrome and type 2 diabetes. Other embodiments are also disclosed.

  本发明揭示了一种双环杂环螺环化合物；包含这些化合物的制药组合物；以及用于治疗哺乳动物中易受M1肌动蛋白受体调节的疾病和病状的方法，包括阿尔茨海默病、胰岛素抵抗综合征和2型糖尿病。还揭示了其他实施例。