neopentyl N-isopropyl phosphoramide | 941-40-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: neopentyl N-isopropyl phosphoramide
• 英文别名: 5,5-dimethyl-2-oxo-N-propan-2-yl-1,3,2lambda5-dioxaphosphinan-2-amine；5,5-dimethyl-2-oxo-N-propan-2-yl-1,3,2λ5-dioxaphosphinan-2-amine
• CAS: 941-40-2
• 化学式: C₈H₁₈NO₃P
• 分子量: 207.21
• InChiKey: XKLQRRUUQDTNNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,5-二甲基-2-氯-1,3,2-二氧磷杂己内酰磷酸酯 、 异丙胺 以 吡啶 、 二氯甲烷 为溶剂， 生成 neopentyl N-isopropyl phosphoramide
  参考文献：
  名称：

  Aryl H-Phosphonates. 6. Synthetic Studies on the Preparation of Nucleoside N-Alkyl-H-phosphonamidates

  摘要：

  Various approaches to the synthesis of nucleoside H-phosphonamidates have been investigated. Direct couplings of nucleoside H-phosphonates with amines have been hampered by extensive reactions of the condensing agents with amines. Preactivation of nucleoside H-phosphonates with pivaloyl chloride or chlorophosphates, followed by the addition of amines, notably diminished these side reactions. The most efficient and versatile route to nucleoside N-alkyl H-phosphonates was found to be aminolysis of the in situ-produced aryl nucleoside H-phosphonates with appropriate amines.

  DOI：

  10.1021/jo962224z

文献信息

• Aryl <i>H</i>-Phosphonates. 6. Synthetic Studies on the Preparation of Nucleoside <i>N</i>-Alkyl-<i>H</i>-phosphonamidates
  作者：Anna Sobkowska、Michał Sobkowski、Jacek Cieślak、Adam Kraszewski、Inger Kers、Jacek Stawiński

  DOI：10.1021/jo962224z

  日期：1997.7.1

  Various approaches to the synthesis of nucleoside H-phosphonamidates have been investigated. Direct couplings of nucleoside H-phosphonates with amines have been hampered by extensive reactions of the condensing agents with amines. Preactivation of nucleoside H-phosphonates with pivaloyl chloride or chlorophosphates, followed by the addition of amines, notably diminished these side reactions. The most efficient and versatile route to nucleoside N-alkyl H-phosphonates was found to be aminolysis of the in situ-produced aryl nucleoside H-phosphonates with appropriate amines.