1,2-Oxathian-2-oxid | 24308-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧硫烷类
• 英文名称: 1,2-Oxathian-2-oxid
• 英文别名: 1,2-Oxathiane 2-oxide；oxathiane 2-oxide
• CAS: 24308-29-0
• 化学式: C₄H₈O₂S
• 分子量: 120.172
• InChiKey: HIBZGXWBEBBKKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2-Oxathian-2-oxid 在 三正丙胺 、 三氯硅烷 作用下， 生成 4,4'-二硫代二丁烷-1-醇
  参考文献：
  名称：

  Reductive formation of disulfides from sulfenyl, sulfinyl, and sulfonyl derivatives using tri-n-propylamine and trichlorosilane

  摘要：

  DOI：

  10.1021/ja00727a048
• 作为产物：
  描述：

  4-巯基-1-丁醇 在 水 、 氯 作用下， 生成 1,2-Oxathian-2-oxid
  参考文献：
  名称：

  An easy preparation of simple sultines and hydroxyalkanesulfinate salts

  摘要：

  DOI：

  10.1016/s0040-4039(00)99119-6

文献信息

• Protein triggered fluorescence switching of near-infrared emitting nanoparticles for contrast-enhanced imaging
  作者：Ragini Jetty、Yuriy P. Bandera、Michael A. Daniele、David Hanor、Hsin-I. Hung、Venkat Ramshesh、Megan F. Duperreault、Anna-Liisa Nieminen、John J. Lemasters、Stephen H. Foulger

  DOI：10.1039/c3tb20681e

  日期：——

  Sub-100 nm colloidal particles which are surface-functionalized with multiple environmentally-sensitive moieties have the potential to combine imaging, early detection, and the treatment of cancer with a single type of long-circulating “nanodevice”. Deep tissue imaging is achievable through the development of particles which are surface-modified with fluorophores that operate in the near-infrared (NIR) spectrum and where the fluorophore's signal can be maximized by “turning-on” the fluorescence only in the targeted tissue. We present a general approach for the synthesis of NIR emitting nanoparticles that exhibit a protein triggered activation/deactivation of the emission. Dispersing the particles into an aqueous solution, such as phosphate buffered saline (PBS), resulted in an aggregation of the hydrophobic fluorophores and a cessation of emission. The emission can be reinstated, or activated, by the conversion of the surface-attached fluorophores from an aggregate to a monomeric species with the addition of an albumin. This activated probe can be deactivated and returned to a quenched state by a simple tryptic digestion of the albumin. The methodology for emission switching offers a path to maximize the signal from the typically weak quantum yield inherent in NIR fluorophores.

  表面功能化具有多种环境敏感基团的亚100纳米胶体粒子，具有将成像、早期检测与治疗癌症结合在一种长循环"纳米装置"中的潜力。通过开发表面修饰有近红外（NIR）光谱范围内工作的荧光团的粒子，并仅在目标组织中"开启"荧光，可以实现深层组织的成像。我们提出了一种合成NIR发射纳米粒子的通用方法，这些纳米粒子表现出由蛋白质触发的激发/失活。将这些粒子分散在磷酸盐缓冲盐水（PBS）等水溶液中，会导致疏水性荧光团的聚集和发射停止。通过添加白蛋白，将表面附着的荧光团从聚集态转变为单体，可以恢复或激活发射。通过简单的胰蛋白酶消化白蛋白，可以使这种激活的探针失活并返回到淬灭状态。发射开关的方法提供了一条途径，以最大化来自NIR荧光团固有的通常较弱的量子产量的信号。
• Organic sulfur chemistry. Part XXII. The reaction of sulfinate esters with Grignard and organocopper lithium reagents. A useful route to chiral sulfoxides
  作者：David N. Harpp、S. Martin Vines、J. P. Montillier、T. H. Chan

  DOI：10.1021/jo00887a012

  日期：1976.12
• King, J. F.; Webster, Michael R.; Chiba, Naoki, Phosphorus and Sulfur and the Related Elements, 1987, vol. 31, p. 161 - 176
  作者：King, J. F.、Webster, Michael R.、Chiba, Naoki、Allen, Julie K.、Parker, Kenneth J. M.、et al.

  DOI：——

  日期：——
• Cathodic reduction of SO2 in the presence of organic dihalides
  作者：Dierk Knittel

  DOI：10.1007/bf00814334

  日期：1982.1
• King, J. F.; Rathore, Rajendra, Phosphorus and Sulfur and the Related Elements, 1987, vol. 33, p. 165 - 172
  作者：King, J. F.、Rathore, Rajendra

  DOI：——

  日期：——

表征谱图