2-formylphenyldihydrogen phosphate | 439904-19-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 2-formylphenyldihydrogen phosphate
• 英文别名: Salicylaldehyd-dihydrogenphosphat；2-phosphonooxy-benzaldehyde；2-Formylphenyl dihydrogen phosphate；(2-formylphenyl) dihydrogen phosphate
• CAS: 439904-19-5
• 化学式: C₇H₇O₅P
• 分子量: 202.103
• InChiKey: BYNSFVCWJXZPOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-formylphenyldihydrogen phosphate 、 7-(二乙氨基)香豆素-3-甲酰肼 以 aq. phosphate buffer 为溶剂， 生成
  参考文献：
  名称：

  正磷酸盐质子交换催化芳醛形成腙的分子内催化

  摘要：

  在体外和活细胞中标记生物分子的生物正交位点特异性化学反应是化学生物学中最强大、最方便的工具之一。经常用于化学共轭的反应对是醛/酮与肼/酰肼/羟胺。尽管该反应通常对这两种成分具有特异性，即使在细胞环境中，该反应在生理条件下也非常缓慢。在芳香醛的邻位添加磷酸基团可将反应速率提高一个数量级，并提高试剂和产物的水溶性。我们已经合成了磷酸盐取代的醛合成模型来研究它们与含有荧光团的肼和酰肼反应的动力学。

  DOI：

  10.1055/s-0035-1561387
• 作为产物：
  描述：

  在 氢气 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以86%的产率得到2-formylphenyldihydrogen phosphate
  参考文献：
  名称：

  正磷酸盐质子交换催化芳醛形成腙的分子内催化

  摘要：

  在体外和活细胞中标记生物分子的生物正交位点特异性化学反应是化学生物学中最强大、最方便的工具之一。经常用于化学共轭的反应对是醛/酮与肼/酰肼/羟胺。尽管该反应通常对这两种成分具有特异性，即使在细胞环境中，该反应在生理条件下也非常缓慢。在芳香醛的邻位添加磷酸基团可将反应速率提高一个数量级，并提高试剂和产物的水溶性。我们已经合成了磷酸盐取代的醛合成模型来研究它们与含有荧光团的肼和酰肼反应的动力学。

  DOI：

  10.1055/s-0035-1561387

文献信息

• Acetal polymers useful in photosensitive compositions
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0752622A1

  公开（公告）日：1997-01-08

  This invention is an acetal polymer having the following repeating units: where R is an alkyl group of 1 to 10 carbon atoms; Ar1 is an aromatic group substituted with an aliphatic group containing 3 to 20 carbon atoms or an alkoxy group having 3 to 20 carbon atoms; Ar2 is a non-substituted aromatic group; A1 is an acid group; n1, n2, n3, n4, n5 represent the molar percents of the respective repeating units and n1 is 0-20 mole %, preferably 2-10 mole %; n2 is 2-20 mole %, preferably 5 to 15 mole %; n3 is 15-85 mole %, preferably 20 to 65 mole %; n4 is 0 to 40 mole %, preferably 0 to 20 mole %; and n5 is 5-40 mole %, preferably 20 to 35 mole %. These polymers may be used in photosensitive compositions and lithographic printing plates.

  本发明是一种具有以下重复单元的缩醛聚合物： 其中 R 是含 1 至 10 个碳原子的烷基； Ar1 是被含 3 至 20 个碳原子的脂肪族基团或含 3 至 20 个碳原子的烷氧基取代的芳香族基团； Ar2 是非取代的芳香族基团； A1 是一个酸基； n1、n2、n3、n4、n5 表示各自重复单元的摩尔百分数，n1 为 0-20摩尔％，最好为 2-10摩尔％；n2 为 2-20摩尔％，最好为 5-15摩尔％；n3 为 15-85摩尔％，最好为 20-65摩尔％；n4 为 0-40摩尔％，最好为 0-20摩尔％；n5 为 5-40摩尔％，最好为 20-35摩尔％。这些聚合物可用于感光组合物和平版印刷板。
• Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein
  作者：Pierre Deprez、Eliane Mandine、Dominique Gofflo、Stéphane Meunier、Dominique Lesuisse

  DOI：10.1016/s0960-894x(02)00140-3

  日期：2002.5

  Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Sre SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised. (C) 2002 Elsevier Science Ltd. All rights reserved.
• ACID-SUBSTITUTED TERNARY ACETAL POLYMERS AND USE THEREOF IN PHOTOSENSITIVE COMPOSITIONS AND LITHOGRAPHIC PRINTING PLATES
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0596941B1

  公开（公告）日：1995-12-13
• METHODS OF IDENTIFYING HIT-ANTIBODIES AND PF4 ANTAGONISTS AND CELL LINES FOR USE THEREIN
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP2828658B1

  公开（公告）日：2017-06-14
• METHOD OF ELECTRICALLY DETECTING A BIOLOGICAL ANALYTE MOLECULE
  申请人：Gao Zhiqiang

  公开号：US20100194409A1

  公开（公告）日：2010-08-05

  The invention provides a method of electrically detecting a biological analyte molecule by means of a pair of electrodes. The electrodes are arranged at a distance from one another within a sensing zone. A capture molecule, which has an affinity to the analyte molecule and which is capable of forming a complex with the analyte molecule, is immobilised on an immobilisation unit. The immobilisation unit is contacted with a solution suspected to comprise the analyte molecule. The analyte molecule is allowed to form a complex with the capture molecule. The invention also provides a probe defined by a nanoparticulate tag that comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule. In the method of the invention the electrically conducting nanoparticulate tag is added. Thereby the electrically conducting nanoparticulate tag is allowed to associate to the complex formed between the capture molecule and the analyte molecule. The presence of the analyte molecule is determined based on an electrical characteristic, influenced by the electrically conducting nanoparticulate tag, of a region in the sensing zone.