N-methyl-N-ethylphosphoramidic dichloride | 777943-34-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: N-methyl-N-ethylphosphoramidic dichloride
• 英文别名: dichloro(N-methylethylamino)oxophosphorus；Ethyl(methyl)phosphoramidic dichloride；N-dichlorophosphoryl-N-methylethanamine
• CAS: 777943-34-7
• 化学式: C₃H₈Cl₂NOP
• 分子量: 175.982
• InChiKey: MTQNYOKDRFNLHT-UHFFFAOYSA-N

物化性质

• 沸点：
  82 °C(Press: 1.5 Torr)
• 密度：
  1.330±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-N-ethylphosphoramidic dichloride 在 tetraphosphorus decasulfide 、 六甲基二硅氧烷 作用下， 以88%的产率得到
  参考文献：
  名称：

  Thionation of phosphoramidodichloridates and phosphoramidate diesters using phosphorus pentasulfide and hexamethyldisiloxane under microwave irradiation. Part 1

  摘要：

  A new, mild, efficient, and solvent-free microwave promoted synthesis of thiophosphoramidodichloridates and thiophosphoramidate diesters is described. The thionation reaction was accelerated with microwave irradiation using the combination of P4S10 and HMDO. The conversion of P=O to P=S by this method gave the desired product in higher yields and shorter reaction times as compared to conventional methods. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.07.099
• 作为产物：
  描述：

  N-乙基甲基胺 在 三氯氧磷 作用下， 以 苯 为溶剂， 生成 N-methyl-N-ethylphosphoramidic dichloride
  参考文献：
  名称：

  使用碱性阴离子交换聚合物树脂/珠粒从二烷基胺和磷酰氯合成 N，N-二烷基磷酰胺二氯

  摘要：

  An efficient and operationally simple method is developed for the synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In the reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.

  DOI：

  10.1515/hc.2009.15.5.361

文献信息

• IONIC LIQUID CONTAINING PHOSPHONIUM CATION HAVING P-N BOND AND METHOD FOR PRODUCING SAME
  申请人：Kanto Denka Kogyo Co., Ltd.

  公开号：EP1956026B1

  公开（公告）日：2016-11-30
• Synthesis Of N, N-Dialkyl Phosphoramidic Dichloride From Dialkyl Amine And Phosphoryl Chloride Using Basic Anion Exchange Polymer Resins/Beads
  作者：Brijesh K. Kushwaha、Hemendra K. Gupta、C. P. Shinde

  DOI：10.1515/hc.2009.15.5.361

  日期：2009.1

  An efficient and operationally simple method is developed for the synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In the reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.
• Thionation of phosphoramidodichloridates and phosphoramidate diesters using phosphorus pentasulfide and hexamethyldisiloxane under microwave irradiation. Part 1
  作者：Manisha Nivsarkar、Arvind K. Gupta、Mahabir P. Kaushik

  DOI：10.1016/j.tetlet.2004.07.099

  日期：2004.9

  A new, mild, efficient, and solvent-free microwave promoted synthesis of thiophosphoramidodichloridates and thiophosphoramidate diesters is described. The thionation reaction was accelerated with microwave irradiation using the combination of P4S10 and HMDO. The conversion of P=O to P=S by this method gave the desired product in higher yields and shorter reaction times as compared to conventional methods. (C) 2004 Elsevier Ltd. All rights reserved.