methyl 2-chloro-4-nitrophenyl phosphate | 7361-70-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: methyl 2-chloro-4-nitrophenyl phosphate
• 英文别名: methyl phosphate；Monomethyl phosphate
• CAS: 7361-70-8
• 化学式: CH₃O₄P
• 分子量: 110.006
• InChiKey: CAAULPUQFIIOTL-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-chloro-4-nitrophenyl phosphate 、 、 1,2,3,4-tetramethylimidazolinium monomethyl carbonate 以 甲醇 为溶剂， 生成 1,2,3,4-Tetramethylimidazolinium methyl phosphate
  参考文献：
  名称：

  Electrolytic solution for aluminum electrolytic capacitors, and aluminum electrolytic capacitor using the same

  摘要：

  本发明提供了一种电解液，用于铝电解电容器，具有高火花电压，同时在30℃下保持其特定电导率为4至25 mS/cm，并且没有腐蚀电容器元件的可能性，以及使用相同电解液的铝电解电容器。本发明的电解液的特点在于，它是一种电解液，包含由下式（1）或（2）表示的烷基磷酸盐阴离子（A）和阳离子（B）组成的电解质（C）以及有机溶剂（D），其中电解液中的磷酸含量为重量的1％或更少： 其中，R1是具有1至10个碳原子的烷基，R2是氢原子或具有1至10个碳原子的烷基。

  公开号：

  US08177994B2
• 作为产物：
  描述：

  methyl 2-chloro-4-nitrophenyl phosphate 在 水 作用下， 以 乙醇 为溶剂， 生成 2-氯-4-硝基苯酚 、 methyl 2-chloro-4-nitrophenyl phosphate
  参考文献：
  名称：

  Enzyme-like Acceleration for the Hydrolysis of a DNA Model Promoted by a Dinuclear Zn(II) Catalyst in Dilute Aqueous Ethanol

  摘要：

  The rates and products of cleavage of methyl (2-chloro-4-nitrophenyl) phosphate (2) promoted by a dinuclear Zn(II) complex (3) of 1,3-bis-N,N'(1,5,9-triazacyclododecyl)propane along with 1 equiv of ethoxide were investigated in ethanol solution containing small amounts of water (8 mM or=1.6 x 10(17) times relative to the background hydroxide reaction, suggesting that complex 3 promotes the hydrolysis at least 1000 times more effectively than ethanolysis.

  DOI：

  10.1021/ja805801j

文献信息

• Preparation of Alkyl Dihydrogenphosphates with Monomeric Metaphosphate Anion Generated by Photochemical C–P Bond Cleavage of<i>p</i>-Nitrobenzylphosphonic Acid
  作者：Narimasa Iwamoto、Yoshiki Okamoto、Setsuo Takamuku

  DOI：10.1246/bcsj.59.1505

  日期：1986.5

  a monomeric metaphosphate anion as an intermediate. The monomeric metaphosphate anions used in this reaction were generated by a photochemical C–P bond cleavage of the p-nitrobenzylphosphonate dianion. The photolysis of a 1:2 molar mixture of p-nitrobenzylphosphonic acid and 1,8-diazabicyclo[5.4.0]undec-7-ene (or 2,2,6,6-tetramethylpiperidine) in excess alcohol gave alkyl dihydrogenphosphate in fairly

  烷基磷酸二氢盐通过可能涉及单体偏磷酸根阴离子作为中间体的程序制备。该反应中使用的单体偏磷酸根阴离子是通过对硝基苄基膦酸二阴离子的光化学 C-P 键断裂产生的。对硝基苄基膦酸和 1,8-二氮杂双环 [5.4.0] 十一碳-7-烯（或 2,2,6,6-四甲基哌啶）的 1:2 摩尔混合物在过量醇中的光解得到磷酸二氢烷基酯良好的产量。
• Method for manufacture of dihydric phenols
  申请人：Oxirane Chemical Co.

  公开号：US03950437A1

  公开（公告）日：1976-04-13

  Dihydric phenols are produced preferentially in high yields by having monohydric phenols or phenyl ethers oxidized by an organic peracid using, as a catalyst, at least one member selected from the group consisting of peracid stabilizers, polycarboxylic acids containing N or OH and possessed of a structure from which heavy metal ion-chelating property can theoretically be assumed, magnesium salts, sodium salts and potassium salts thereof, sodium salt, potassium salt and lower alkyl esters of phosphoric acid, and sodium salt and lower alkyl esters of pyrophosphoric acid.

  二元酚可以通过使用有机过氧酸氧化单元酚或苯基醚，同时使用过氧酸稳定剂、含有N或OH的多羧酸催化剂，具有理论上可以假定重金属离子螯合性质的结构、镁盐、其钠盐、钾盐和磷酸的较低烷基酯、以及焦磷酸的钠盐和较低烷基酯，从而以高产率优先制备。
• ELECTROLYTIC SOLUTION FOR ALUMINUM ELECTROLYTIC CAPACITORS, AND ALUMINUM ELECTROLYTIC CAPACITOR USING THE SAME
  申请人：Taguchi Shinya

  公开号：US20090256105A1

  公开（公告）日：2009-10-15

  The present invention provides an electrolytic solution for aluminum electrolytic capacitors which has a high sparking voltage while maintaining its specific conductivity at 30° C. of 4 to 25 mS/cm and which has no possibility of corroding capacitor elements, and an aluminum electrolytic capacitor using the same. The electrolytic solution of the present invention is characterized as being an electrolytic solution containing an electrolyte (C) composed of an alkyl phosphate anion (A) represented by formula (1) or (2) given below and a cation (B), and an organic solvent (D), wherein the content of phosphoric acid in the electrolytic solution is 1% by weight or less: wherein R 1 is an alkyl group having 1 to 10 carbon atoms and R 2 is a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.

  本发明提供了一种铝电解电容器的电解液，其具有高的放电电压，同时在30℃下保持其特定电导率为4至25 mS/cm，且不可能腐蚀电容器元件，以及使用相同电解液的铝电解电容器。本发明的电解液的特点在于，它是一种电解液，包含由下式（1）或（2）表示的烷基磷酸酯阴离子（A）组成的电解质（C）和阳离子（B）以及有机溶剂（D），其中电解液中磷酸的含量为1重量％或更少：其中R1是具有1至10个碳原子的烷基，R2是氢原子或具有1至10个碳原子的烷基。
• 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPAI ANTAGONISTS
  申请人：Kumar Sukeerthi

  公开号：US20120157411A1

  公开（公告）日：2012-06-21

  The present invention is related to 2-amino-4-arylthiazole derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及2-氨基-4-芳基噻唑衍生物作为TRPA（瞬时受体电位亚家族A）调节剂。特别地，本文所描述的化合物对于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、症状和/或紊乱是有用的。此外，本文还提供了制备所述化合物的方法、用于合成的中间体、其制药组合物以及治疗或预防由TRPA1调节的疾病、症状和/或紊乱的方法。
• 2-amino-4-arylthiazole compounds as TRPA1 antagonists
  申请人：Kumar Sukeerthi

  公开号：US08592398B2

  公开（公告）日：2013-11-26

  The present invention is related to 2-amino-4-arylthiazole derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及2-氨基-4-芳基噻唑衍生物作为TRPA（瞬时受体电位亚家族A）调节剂。特别地，本文所描述的化合物对于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、状况和/或紊乱是有用的。本文还提供了制备所述化合物的过程，用于其合成的中间体，其制药组合物以及治疗或预防由TRPA1调节的疾病、状况和/或紊乱的方法。