Spiro(piperidin-1,4'-morpholinium) bromide | 16450-39-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: Spiro(piperidin-1,4'-morpholinium) bromide
• 英文别名: 3-Oxa-6-azoniaspiro[5.5]undecane;bromide
• CAS: 16450-39-8
• 化学式: Br*C₉H₁₈NO
• 分子量: 236.152
• InChiKey: LEKZYCJJXCUAPD-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.98
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Spiro(piperidin-1,4'-morpholinium) bromide 、 氢氧化钾 生成 N-(β-Vinyloxyethyl)piperidin
  参考文献：
  名称：

  MOVSUMZADE M. M.; GURBANOV P. A.; SEIDOV M. A.; XODZHAEV G. X., MEHPYZHEHLEHR. AZSSR ELMLEHR AKAD., DOKL. AN AZSSR, 1979, 35, HO 11, 60-6+

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2'-二溴二乙醚 、 哌啶 以86%的产率得到
  参考文献：
  名称：

  MOVSUMZADE M. M.; GURBANOV P. A.; SEIDOV M. A.; XODZHAEV G. X., MEHPYZHEHLEHR. AZSSR ELMLEHR AKAD., DOKL. AN AZSSR, 1979, 35, HO 11, 60-6+

  摘要：

  DOI：

文献信息

• Insight into the Alkaline Stability of N‐Heterocyclic Ammonium Groups for Anion‐Exchange Polyelectrolytes
  作者：Nanjun Chen、Yiqi Jin、Haijun Liu、Chuan Hu、Bo Wu、Shaoyi Xu、Hui Li、Jiantao Fan、Young Moo Lee

  DOI：10.1002/anie.202105231

  日期：2021.8.23

  nucleophilic substitution is the dominant degradation pathway in NHAs, while Hofmann elimination is the primary degradation pathway for NHA-based AEMs. Different degradation pathways determine the alkaline stability of NHAs or NHA-based AEMs. AEMFC durability (from 1 A cm−2 to 3 A cm−2) suggests that NHA-based AEMs are mainly subjected to Hofmann elimination under 1 A cm−2 current density for 1000 h, providing

  N-杂环铵 (NHA) 基团的碱性稳定性是阴离子交换膜 (AEM) 和 AEM 燃料电池 (AEMFC) 的关键课题。在这里，我们报告了对 24 个代表性 NHA 基团在不同水合数（λ) 在 80 °C。结果表明，含有给电子基团的 γ 取代 NHA 显示出优异的碱性稳定性，而吸电子取代基对耐久的 NHA 有害。密度泛函理论计算和实验结果表明，亲核取代是 NHA 的主要降解途径，而霍夫曼消除是基于 NHA 的 AEM 的主要降解途径。不同的降解途径决定了 NHA 或基于 NHA 的 AEM 的碱性稳定性。AEMFC 耐久性（从 1 A cm -2到 3 A cm -2）表明基于 NHA 的 AEM 主要在 1 A cm -2电流密度下进行 1000 小时的霍夫曼消除，从而深入了解电流密度与λ之间的关系 基于 NHA 的 AEM 的价值和耐久性。
• ORGANO-1-OXA-4-AZONIUM CYCLOHEXANE COMPOUNDS
  申请人：UOP LLC

  公开号：US20160159760A1

  公开（公告）日：2016-06-09

  Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

  描述了新型的1-oxa-4-azonium环己烷盐。这些化合物可用作结构导向剂，并且克服了与OSDA合成和随后的沸石合成相关许多典型问题。还描述了从各种起始材料合成1-oxa-4-azonium环己烷盐的方法。 将取代的烃加入水中形成混合物，然后加入1-oxa-4-azacyclohexane衍生物。搅拌反应混合物，直到获得含有1-oxa-4-azonium环己烷盐的溶液。
• Potentiation of acetylcholinesterase by a series of quaternary ammonium compounds
  作者：B D Roufogalis、J Thomas

  DOI：10.1111/j.2042-7158.1968.tb09703.x

  日期：2011.4.12

  Eleven spiran, and two non-spiran, quaternary ammonium compounds have been examined and some of these compounds found to potentiate the hydrolysis of acetylcholine by acetylcholinesterase at high substrate concentrations. The experiments were made in three reaction media, each differing in its ionic composition. The results obtained in these media differ both quantitatively and qualitatively. The mechanism of the potentiation is discussed in terms of the effect of quaternary ammonium compounds on the deacetylation step of acetylcholine hydrolysis.

  标题：摘要 十一个螺旋和两个非螺旋的季铵化合物已经被检验，其中一些化合物被发现在高底物浓度下增强乙酰胆碱酯酶对乙酰胆碱的水解作用。实验在三种反应介质中进行，每种介质在离子组成上有所不同。在这些介质中获得的结果在数量和质量上都有所不同。通过讨论季铵化合物对乙酰胆碱水解的去乙酰化步骤的影响，探讨了增强作用的机制。
• 고리형 4차 암모늄 염, 그 제조방법 및 상기 고리형 4차 암모늄 염을 이용한 전기이중층 커패시터
  申请人：Sangmyung University Industry-Academy Cooperation Foundation 상명대학교산학협력단(120130115290) Corp. No ▼ 110371-0013146BRN ▼101-82-22512

  公开号：KR20150125166A

  公开（公告）日：2015-11-09

  본 발명은, 하기의 구조식을 갖는 고리형 몰포리늄 4차 암모늄 BF 염으로서 3-옥사-6-아자스피로[5.5]운데칸-6-이움 테트라플루오로보레이트이고, [구조식] 상기 구조식에서 'R'은 H, 메틸, 에틸 및 프로필 중에서 선택된 1종 이상의 작용기를 포함하는 것을 특징으로 고리형 4차 암모늄 염, 그 제조방법 및 상기 고리형 4차 암모늄 염을 이용한 전기이중층 커패시터에 관한 것이다. 본 발명의 고리형 4차 암모늄 염은 전기이중층 커패시터의 전해액으로 사용될 수 있고 출력용량이 우수하다.

  本发明涉及具有以下结构式的环状孔隙氮4价铵BF盐，其中3-氧杂-6-氮杂双[5.5]芴-6-锂四氟硼酸盐，[结构式] 在上述结构式中，“R”代表H、甲基、乙基和丙基中选择的一个或多个基团，特征是环状4价铵盐，其制备方法以及涉及使用该环状4价铵盐的电解双层电容器。本发明的环状4价铵盐可用作电解双层电容器的电解液，具有优异的输出容量。
• Organo-1-oxa-4-azonium cyclohexane compounds
  申请人：UOP LLC

  公开号：US10597373B2

  公开（公告）日：2020-03-24

  Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

  本文介绍了新型 1-oxa-4-azonium 环己烷盐。 这些化合物可用作结构引导剂，克服了与 OSDA 合成和后续沸石合成相关的许多典型问题。 此外，还介绍了从各种起始材料合成 1-oxa-4-azonium 环己烷盐的方法。 将取代的碳氢化合物加入水中形成混合物，然后加入 1-oxa-4-azacyclohexane 衍生物。 搅拌反应混合物，直到得到含有 1-oxa-4-azium 环己烷盐的溶液。