1-ethyl-2-methylimidazoline | 4814-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 亚胺内酰胺
• 英文名称: 1-ethyl-2-methylimidazoline
• 英文别名: 1-ethyl-2-methyl-4,5-dihydroimidazole
• CAS: 4814-93-1
• 化学式: C₆H₁₂N₂
• 分子量: 112.175
• InChiKey: VMZNMSUASLBPDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-ethyl-2-methylimidazoline 在 水 作用下， 以 甲醇 为溶剂， 20.0~145.0 ℃ 、861.32 kPa 条件下， 反应 13.5h， 生成 1-ethyl-2,3-dimethylimidazolinium hydrogen phthalate salt
  参考文献：
  名称：

  JP6323106

  摘要：

  公开号：
• 作为产物：
  描述：

  2-甲基咪唑啉 、 溴乙烷 在 sodium hydroxide 、 四丁基溴化铵 、 potassium carbonate 作用下， 反应 1.5h， 以60%的产率得到1-ethyl-2-methylimidazoline
  参考文献：
  名称：

  N-Alkylation of 2-Methyl-2-Imidazolines by Phase Transfer Catalysis Without Solvent

  摘要：

  1-Alkyl-2-methyl-2-imidazolines were obtained ill go od to excellent yields by alkylation of 2-methyl-2-imidazoline with organic halides in the presence of phase transfer catalysis and absence of solvent.

  DOI：

  10.1080/00397919908086479

文献信息

• Phenoxypropylamine compounds
  申请人：——

  公开号：US20020111358A1

  公开（公告）日：2002-08-15

  The present invention relates to a phenoxypropylamine compound of the formula (I) 1 wherein each symbol is as defined in the specification, an optically active compound thereof or a pharmaceutically acceptable salt thereof and hydrates thereof, which simultaneously show selective affinity for and antagonistic activity against 5-HT 1A receptor, as well as 5-HT reuptake inhibitory activity, and can be used as antidepressants quick in expressing an anti-depressive effect.

  本发明涉及一种公式（I）中的苯氧丙胺化合物： 1 其中每个符号如说明书中所定义，其光学活性化合物或其药物可接受的盐及水合物，同时显示出对5-HT 1A 受体的选择性亲和力和拮抗活性，以及5-HT再摄取抑制活性，并且可以用作快速表达抗抑郁效果的抗抑郁药。
• Six-Membered Cyclic Amidines as Efficient Catalysts for the Synthesis of Cyclic Dithiocarbonates from Carbon Disulfide and Epoxides under Mild Conditions
  作者：Naoto Aoyagi、Takeshi Endo

  DOI：10.1055/s-0039-1690266

  日期：2020.1

  Six-membered cyclic amidines effectively catalyzed the reaction of carbon disulfide with epoxides under mild conditions, such as atmospheric pressure and ambient temperature, to give the corresponding cyclic dithiocarbonates (1,3-oxathiolane-2-thiones) in high yields.

  六元环脒在温和条件下（如常压和室温）有效催化二硫化碳与环氧化物的反应，以高产率得到相应的环状二硫代碳酸酯（1,3-oxathiolane-2-thiones）。
• Structural Aspects of Thermally Cleavable Adducts Derived from the Reaction of Imidazolines with Isocyanates
  作者：Stefan Spange、Andreas Laue、Andrea Preuß、Manuel Heck、Mandy Martin、Marcus Binner、Tobias Rüffer、Susann Anders、Carsten Werner、Lothar Kroll、Heinrich Lang

  DOI：10.1055/s-0035-1562626

  日期：——

  pyrimidinediones. Thermal analysis (TG-MS/DSC) and trapping reactions with nucleophilic reagents, such as diphenylamine, show the release of isocyanate during the thermally induced cleavage reaction. Thus, blocked isocyanates are available by the reaction of isocyanates with 1-ethylimidazoline or 1-ethyl-2-isopropylimidazoline. The reaction of isocyanates with substituted imidazolines and the thermally induced

  摘要 给出了异氰酸酯与取代的咪唑啉的反应以及所得加合物的热诱导裂解。为此，已经研究了各种异氰酸酯[异氰酸乙酯，对甲基苯基异氰酸酯，苯基异氰酸酯，对-（三氟甲基）苯基异氰酸酯]与1-烷基咪唑啉衍生物的反应，该反应是咪唑啉在2-位的取代基的函数。戒指。3当量的异氰酸酯与1当量的1-乙基咪唑啉反应，得到化学计量明确的加合物。然而，1-乙基-2-异丙基咪唑啉在0°C下与异氰酸酯发生另一种反应，形成2：1加合物，它们属于1,3-二苯基四氢咪唑并[1,2- a ] [1,3， 5] triazine-2,4（1 H，3 H）-二酮。1-乙基-2-甲基咪唑啉与芳族异氰酸酯在0°C的反应还会生成2：1加合物，在这种情况下为丙二酰胺类型，可以在60°C与另外的异氰酸酯等效物反应生成已知的嘧啶二酮。热分析（TG-MS / DSC）以及与亲核试剂（例如二苯胺）的捕集反应表明，在热诱导的裂解反应过程中释放出异氰酸
• Inhibitors of factor Xa
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20040116399A1

  公开（公告）日：2004-06-17

  Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

  本发明揭示了一种具有对哺乳动物因子Xa活性的新化合物、其盐和相关组合物。这些化合物在体外或体内用于预防或治疗凝血障碍。
• Electrolyte for electrolytic capacitor, electrolytic capacitor and process for producing tetrafluoroaluminate salt of organic onium
  申请人：Takeda Masayuki

  公开号：US20060007629A1

  公开（公告）日：2006-01-12

  There are provided an aluminum electrolytic capacitor comprising an anode, a cathode comprising aluminum and an electrolytic solution containing an onium salt of fluorine-containing anion, wherein the electrolytic solution has a water concentration of 1% by weight or less, or wherein the cathode has a peak top of Al2p spectrum of 74.0 to 75.8 eV as measured by a method in which the surface of the cathode in the aluminum electrolytic capacitor heated at 125° C. for 50 hours is analyzed by X-ray photoelectron spectroscopy (XPS); an electrolytic solution for electrolytic capacitor comprising a quaternary cyclic amidinium tetrafluoroaluminate and a solvent and containing specific impurity compounds in a total amount of 0.6% by weight or less, and an electrolytic capacitor using the electrolytic solution; and a method for preparing an organic onium tetrafluoroaluminate which is advantageously m used in an aluminum electrolytic capacitor.

  提供了一种铝电解电容器，包括阳极、铝制阴极和含有含氟阴离子的有机盐的电解质溶液，其中电解质溶液的水浓度为重量的1％或以下，或者阴极的Al2p谱峰顶在74.0至75.8电子伏特之间，通过X射线光电子能谱（XPS）分析在125℃下加热50小时的铝电解电容器中阴极表面测量得到；一种电解电容器用的电解质溶液，包括四元环酰胺铝酸四氟铝酸盐和溶剂，并且总杂质化合物的含量为重量的0.6％或以下；以及一种用于制备有机盐的四氟铝酸盐的方法，该有机盐优选用于铝电解电容器。