(fluoro)dihydroborane | 27944-03-2

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 类金属盐
• 英文名称: (fluoro)dihydroborane
• 英文别名: fluoroborane
• CAS: 27944-03-2
• 化学式: BFH₂
• 分子量: 31.8253
• InChiKey: BVBRZOLXXOIMQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (fluoro)dihydroborane 、 乙炔 生成 ((1Z,1'Z)-(fluoroboranediyl)bis(ethene-2,1-diyl))bis(difluoroborane)
  参考文献：
  名称：

  Boron-fluorine chemistry. II. Reaction of boron monofluoride with acetylenes

  摘要：

  DOI：

  10.1021/ja01019a014
• 作为产物：
  描述：

  三氟化硼 、 diborane(6) 以 neat (no solvent, gas phase) 为溶剂， 以0%的产率得到(fluoro)dihydroborane
  参考文献：
  名称：

  氟硼烷，BH2F的微波光谱检测

  摘要：

  摘要氟硼烷。BH2F 已被微波光谱技术检测为乙硼烷与三氟硼烷反应中的一种瞬态化学物质。为该分子的三个同位素物种获得的旋转常数为（以 MHz 为单位）： [公式] 已确定 11BD2F 的偶极矩为 μa = 0.82 (5) D。四极耦合常数和分子结构也已确定。

  DOI：

  10.1006/jmsp.1993.1066

文献信息

• BICYCLIC GPR119 MODULATORS
  申请人：Thotapally Rajesh

  公开号：US20130245000A1

  公开（公告）日：2013-09-19

  The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).

  本发明涉及化合物(I)的使用，该化合物对于治疗、预防和/或管理与GPR119受体活性调节相关的疾病、紊乱、综合症或病况是有用的。本发明还涉及该化合物的制备过程、制药组合物。本发明还涉及使用化合物(I)单独或与其他化合物联合治疗、预防和/或管理与GPR119受体活性调节相关的疾病、紊乱、综合症或病况的方法。
• Bicyclic GPR119 modulators
  申请人：Thotapally Rajesh

  公开号：US09000175B2

  公开（公告）日：2015-04-07

  The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).

  本发明涉及式（I）的化合物，其有助于治疗、预防和/或管理与调节GPR119受体活性相关的疾病、疾病、综合征或疾病。本发明还涉及制备该化合物的过程，以及其制药组合物。本发明还涉及使用式（I）的单独或组合治疗、预防和/或管理与调节GPR119受体相关的疾病、疾病、综合征或疾病的方法。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: B: B-Verb.9, 6.1, page 258 - 268
  作者：

  DOI：——

  日期：——
• Mass‐Spectrometric Studies of the Synthesis, Energetics, and Cryogenic Stability of the Lower Boron Hydrides
  作者：J. H. Wilson、H. A. McGee

  DOI：10.1063/1.1840872

  日期：1967.2.15

  Ionization-efficiency measurements on species produced in the pyrolysis of B2H6 have led to A (B+), A (BH+), A (BH2+), A (BH3+), and A (B2H5+) from B2H6 and to A (B+), A (BH+), A (BH2+), and I (BH3) from BH3. These experimental results have permitted a rather complete development of the energetics of the BH3; B2H6 system and its related radicals and ions, including the important symmetric dissociation energy, D (BH3–BH3), which was found to be 2.56 eV. BH2 was not observed in these experiments and thermodynamic and kinetic arguments, using the results of this investigation, predict that BH2 should be of little significance in the pyrolysis mechanism. Using a cryogenically cooled mass-spectrometric system the existence of BH3 and BH2F as stable cryochemicals was explored at temperatures down to 55°K with negative results.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: B: B-Verb.9, 1.3.1, page 32 - 33
  作者：

  DOI：——

  日期：——