methyl-N,N-dimethylphosphoroamidochloridate | 65513-43-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: methyl-N,N-dimethylphosphoroamidochloridate
• 英文别名: phosphoric acid-chloride dimethylamide-methyl ester；N,N-Dimethyl-amidophosphorsaeure-chlorid-methylester；Phosphorsaeure-chlorid-dimethylamid-methylester；phosphoric acid chloride dimethylamide methyl ester；Dimethylamino-methoxy-chloro-phosphinoxid；N,N-dimethyl phosphoramido chloridic acid methyl ester；N-[chloro(methoxy)phosphoryl]-N-methylmethanamine
• CAS: 65513-43-1
• 化学式: C₃H₉ClNO₂P
• 分子量: 157.537
• InChiKey: MXGKTQLAHWEVOV-UHFFFAOYSA-N

物化性质

• 沸点：
  72 °C(Press: 5 Torr)
• 密度：
  1.2510 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl-N,N-dimethylphosphoroamidochloridate 在 氢氧化钾 作用下， 生成 dimethyl-amidophosphoric acid monomethyl ester
  参考文献：
  名称：

  Braeuninger,M. et al., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1979, vol. 34, p. 1703 - 1710

  摘要：

  DOI：
• 作为产物：
  描述：

  二甲胺 、 二氯磷酸甲酯 以 乙醚 为溶剂， 以69%的产率得到methyl-N,N-dimethylphosphoroamidochloridate
  参考文献：
  名称：

  Symes, Jill; Modro, Tomasz A., Canadian Journal of Chemistry, 1986, vol. 64, p. 1702 - 1708

  摘要：

  DOI：

文献信息

• Substituted thiazolidinyl esters of mineral acids
  申请人：Ciba-Geigy Corporation

  公开号：US04582841A1

  公开（公告）日：1986-04-15

  Compounds of the formula ##STR1## in which one of the symbols R.sub.1 and R.sub.2 represents an alkyl radical that has 3 or 4 carbon atoms and is unsaturated in the 2,3-position, and the other represents such a radical or lower alkyl, R.sub.3 and R.sub.4 each represents, independently of the other, hydrogen or methyl, and A represents a radical of the formula ##STR2## in which Z.sub.1, or each of Z.sub.2 and Z.sub.3 independently of the other, represents hydrogen or lower alkyl, or Z.sub.2 and Z.sub.3 together represent lower alkylene, each of R.sub.5 and R.sub.6, independently of the other, represents hydrogen, lower alkyl, halogenated lower alkyl, or lower alkenyl or R.sub.5 and R.sub.6 together represent lower alkylene that is optionally interrupted by oxygen, sulphur or by optionally substituted nitrogen, and X represents OR.sub.7 or NR.sub.8 R.sub.9 in which R.sub.7 represents hydrogen or lower alkyl and each of R.sub.8 and R.sub.9, independently of the other, represents hydrogen, lower alkyl, halogenated lower alkyl, or lower alkenyl or R.sub.8 and R.sub.9 together represent lower alkylene that is optionally interrupted by oxygen, sulphur or by optionally substituted nitrogen, or R.sub.6 together with R.sub.7 or R.sub.8 represents a lower alkylene group Alk, and salts of such compounds in which Z.sub.1, or Z.sub.3 and optionally also Z.sub.2, or R.sub.7 represent(s) hydrogen, exhibit tumor-inhibiting activities.

  式为##STR1##的化合物，其中R.sub.1和R.sub.2中的一个代表具有3或4个碳原子且在2,3位不饱和的烷基基团，另一个代表这样的基团或更低的烷基，R.sub.3和R.sub.4分别独立地代表氢或甲基，A代表式##STR2##的基团，在该式中，Z.sub.1或Z.sub.2和Z.sub.3中的每一个独立地代表氢或更低的烷基，或Z.sub.2和Z.sub.3一起代表更低的烷基，R.sub.5和R.sub.6中的每一个独立地代表氢，更低的烷基，卤代更低的烷基或更低的烯基，或R.sub.5和R.sub.6一起代表可以由氧、硫或者可选取代的氮中断的更低的烷基，X代表OR.sub.7或NR.sub.8R.sub.9，在该式中，R.sub.7代表氢或更低的烷基，R.sub.8和R.sub.9中的每一个独立地代表氢、更低的烷基、卤代更低的烷基或更低的烯基，或R.sub.8和R.sub.9一起代表可以由氧、硫或者可选取代的氮中断的更低的烷基，或R.sub.6与R.sub.7或R.sub.8一起代表更低的烷基Alk，以及这种化合物的盐，其中Z.sub.1或Z.sub.3并且可选取Z.sub.2或R.sub.7代表氢，表现出抑制肿瘤的活性。
• Development of an Isolable Active Ester, Diethyl Thiophosphoryl [(Z)-(2-Aminothiazol-4-yl)-2-(Methoxyimino)acetate (DAMA) for the Synthesis of Cefotaxime
  作者：Man-Young Yoon、Hee-Bong Lee、Hyun-Ik Shin

  DOI：10.5012/bkcs.2011.32.2.407

  日期：2011.2.20

  An isolable activated ester, diethyl thiophosphoryl [(Z)-(2-aminothiazol-4-yl)-2-(methoxyimino)acetate (9a, DAMA) was prepared in high purity, which was at least stable for 7 d at $25^\circ}C$ and 6 months at $5^\circ}C$. Its reaction with 7-ACA (4) in the presence of tributylamine in i-PrOH provided cefotaxime (1) of high purity in good yield. Preparation of DAMA and its reaction with 7-ACA (4) to 1 was performed in one-pot manner, respectively with minimal unit operations of stirring and filtration.

  制备出一种可分离的活化酯，硫代磷酰[(Z)-(2-氨基噻唑-4-基)-2-(甲氧基亚氨基)乙酸二乙酯（9a，DAMA），纯度高，在$25^\circ}C$下至少可稳定7天，在$5^\circ}C$下可稳定6个月。它与 7-ACA (4) 在三丁胺存在下于 i-PrOH 中反应，得到了高纯度、高收率的头孢他啶 (1)。DAMA 的制备及其与 7-ACA (4) 反应生成 1 的过程均以一锅法进行，只需搅拌和过滤等最少的单元操作。
• Organic Polyphosphorus Compounds. II. Phosphorylations with Aliphatic Amido Polyphosphates and Polymetaphosphates
  作者：Henry Tolkmith

  DOI：10.1021/ja01117a038

  日期：1953.11
• Symes, Jill; Modro, Tomasz A., Canadian Journal of Chemistry, 1986, vol. 64, p. 1702 - 1708
  作者：Symes, Jill、Modro, Tomasz A.

  DOI：——

  日期：——
• Braeuninger,M. et al., Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1979, vol. 34, p. 1703 - 1710
  作者：Braeuninger,M. et al.

  DOI：——

  日期：——